摘要
目的利用四氯化碳诱导大鼠急性肝损伤模型,研究小球藻提取物对急性肝损伤的保护作用。方法利用四氯化碳诱导大鼠急性肝损伤,测定大鼠血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性,肝组织中谷胱甘肽(GSH)、丙二醛(MDA)水平及谷胱甘肽过氧化酶(GSH-Px)活性,分析小球藻提取物对上述指标的影响。结果小球藻提取物显著降低大鼠血清中ALT,AST以及肝组织中MDA值并促进肝组织中GSH-Px活性及GSH含量的升高。结论小球藻提取物对四氯化碳所致大鼠急性肝损伤具有明显的防治作用。
Objective To study the protective effects of aqueous extract of Chlorella vulgaris （AEC） against CCl4 - induced hepatic injury in rats. Methods The activities of serum ALT and AST were detected. The levels of hepatic GSH and MDA and the activity of GSH - Px in the liver were also determined. Results The activities of serum AST, ALT and the degree of hepatic MDA were reduced significantly by AEC. Meanwhile, AEC restored the hepatic GSH content and GSH - Px activity. Conclusion AEC has a good protective effect on acute hepatic injury in rats.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第1期163-164,共2页
Lishizhen Medicine and Materia Medica Research
关键词
小球藻
四氯化碳
肝损害
Chlorella vulgaris
Carbon tetrachloride （CC14）
Hepatoprotective
