摘要
目的:了解重症药疹的临床特征、治疗及预后。方法:回顾性分析笔者所在科室1998—2007年62例住院重症药疹患者的临床资料,其中大疱性表皮坏死松解型29例,重症多形红斑型22例,剥脱性皮炎型11例。在局部用药的同时,均早期应用大剂量糖皮质激素治疗[剂量相当于泼尼松1.0～2.5 mg/(kg·d)]。结果:62例患者中治愈51例,好转5例,死亡6例(均为大疱性表皮坏死松解型患者)。结论:对重症药疹患者应及早使用足量糖皮质激素,加强支持疗法,这是稳定病情、降低死亡率的关键。
Objective： To study the clinical feature, treatment patients （39 males,23 females, 2 to 74 years old） with severe and prognosis of severe drug eruption. Methods： Sixty-two indrug eruptions were analyzed retrospectively, including 29 patients with bullous epidermal necrolysis, 22 patients with erythema multiforme major and 11 patients with exfoliative dermatitis. Early treatment with large doses of intravenous glucoeorticoid, approximately equal to prednisone 1.0-2.5 mg/（kg·d）, was given in all the cases, at the same time with topical treatment. Results： Fifty-one out of 62 patients were cured, 5 improved, and 6 died of bullous epidermal necrolysis. Conclusion： It is important to give sufficient glueoeorticoid earlier in the treatment of severe drug eruption, which may be helpful to control the disease and lower the mortality rate.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2009年第2期86-88,共3页
Journal of Clinical Dermatology
关键词
药疹
重症
临床分析
drug eruption, severe
clinical analysis
