摘要
目的观察不同程度急性等容性血液稀释对常温下家兔脑氧代谢的影响。方法32只成年家兔,随机均分为A、B、C、D四组,A、B、C三组的目标Hct分别为24%、18%、12%;D组为对照组,不行血液稀释。以20%乌拉坦行静脉麻醉后机械通气,并维持体温在37℃。监测血液稀释前后的动、静脉血气,并根据Fick’s公式计算出脑氧代谢率(CERO2)。结果A组各时点CERO2与D组比较差异无统计学意义,B组CERO2在血液稀释后8h较基础值增高,而C组CERO2在血液稀释后2、4、8h均较基础值增高。结论血液稀释目标Hct为24%时,对常温、有创条件下家兔脑氧代谢并无影响;目标Hct为18%时,在血液稀释后8h可以出现CERO2增高,且血液pH值明显降低;血液稀释至Hct为12%时则不能满足脑氧代谢需求。
Objective To investigate the effects of acute normovolemic hemodilution（ANH） with 6% HES on rabbit cerebral oxygen metabolism （CERO2）. Methods Thirty-two rabbits anasthetized with intravenous ethyl carbamate and mechanically ventilated were divided into 4 groups with 8 rabbits each. Body temperature were maintained in 37℃. ANH was performed with 6% HES producing the hemotercrit of 24% （group A）, 18% （group B） or 12 % （group C）, and the rabbits in group D were not given ANH as the controls. Blood samples from the jugular vein and artery were withdrawn at 2,4 and 8 h after ANH for blood gas analysis, by which CERO2 was calculated according to Fick,s formula. Results The CERO2 of group A was similar to that of group D. Compaered with that before ANH, CERO2 raised at 8 h in group B, and at 2 to 8 h group C after hemodilution. Conclusion Under body temperature of 37℃ ,Hct at 24% has no effect on.CERO2 ,which is reduced when Hct is at 18% ,and Hct at 12% can not fulfill the requiments of CERO2.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2009年第1期51-54,共4页
Journal of Clinical Anesthesiology
