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骨肿瘤患者血清骨钙素的变化及其临床意义 被引量:2

The change of serum BGP level in the bone tumor patients and its clinical importance
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摘要 目的测定骨肿瘤患者血清BGP和AKP值。方法68例中,骨巨细胞瘤18例,骨肉瘤15例,软骨瘤16例,骨软骨瘤19例,在治疗前和治疗后清晨空腹取静脉血4~5ml,血液凝固后,离心,取血清行BGP放射免疫测定(RIA)。结果血清BGP在骨肿瘤患者中显著高于正常对照组,在治疗后降至正常范围,血清AKP只在骨肉瘤患者中显著升高。结论①.血清BGP是反映骨肿瘤及其它代谢性骨病患者骨代谢的一个特异的、灵敏而简便的生化指标,并对骨肿瘤的鉴别诊断及观察预后具有一定的临床意义;②.作为骨肿瘤及其它代谢性骨病的检测指标,血清BGP较AKP更为敏感。 Objective Detected serum BGP and AKP level of bone tumor patients.Methods 68 patients were studied, including 18 giant cell tumors of bone, 15 osteosarcomas, 16 chondromas, 19 osteo chondromas. Peripheralvenous blood samples(about 4~5ml) were drawn from the patients with empty stomach in the morning before and after treatment. After clotting, the samples were centrifugated and the surum BGP were assayed by radio-immunoassay(RIA).Results Serum BGP level was higher in the patients of bone tumor than that in the control, and it came down after treatment. Serum AKP increased only in the osteosarcoma patients.Conclusions 1. Serum BGP was a peculiar, sensitive and convenient biochemical index which reflected metabolism of patients of bone tumors and other metabolic osteopathies, More over, it had some clinical importance for differential diagnosis and observations of prognoses of bone tumors. 2. As an index of bone tumors and other metabolic osteopathies, serum BGP was sensitiver than the AKP.
机构地区 兰州解放军第
出处 《宁夏医学杂志》 CAS 1998年第1期5-6,共2页 Ningxia Medical Journal
关键词 骨肿瘤 骨钙素 碱性磷酸酶 Bone tumor Osteocalcin Alkaline phosphatase
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