摘要
妊娠期间甲状腺激素的合成、分泌、代谢、调节及甲状腺免疫环境均发生相应的改变,而甲状腺功能障碍亦可从月经、排卵、受孕、胚胎分化、分娩等各阶段影响妊娠结局。已发现,即使是亚临床甲状腺功能减退症,或甲状腺功能正常的自身免疫性甲状腺疾病,对妊娠亦产生不良影响。因此妊娠合并甲状腺功能减退症的早期诊断尤为重要。目前促甲状腺激素(TSH)仍作为诊断妊娠期甲状腺疾病首选的指标,推荐将2.5mU/L作为妊娠早期母体血清TSH水平的保守上限值。有自身免疫性甲状腺疾病者在妊娠期发生甲状腺功能不足的几率较高,需密切监测。
The synthesis, secretion, metabolism and regulation of thyroid hormones during pregnancy all change with gestational age as well as thyroid immunity. At the same time, dy^unctions of the thyroid can influence menstruation, ovulation, fe ＂rtdization, embryonic differentiation and delivery, thus affecting the pregnancy outcome. In the present review, we discuss the various effects of hypothyroidism during pregnancy. Of note, even subclinical hypothyroidism or autoimmune thyroid disease with euthyroidism can adversely impact pregnancy. Therefore, the early diagnosis and treatment of hypothyroidism during the gestational period is especially important. At present, thyrotrophic-stimulating hormone（TSI-I） is used as the first-line marker for diagnosis of thyroid disease in pregnancy. A TSH level of 2.5 mIU/L is recommended as an appropriate conservative upper limit for the first trimester of pregnancy. However, pregnant women with autoimmune thyroid disease are at an increased risk for thyroid insufficiency, and should be closely monitored throughout their pregnancy.
出处
《国际妇产科学杂志》
CAS
2009年第1期30-33,共4页
Journal of International Obstetrics and Gynecology
基金
江苏省社会发展基金(BS2004039)
关键词
甲状腺功能减退症
自身免疫性甲状腺疾病
自然妊娠
辅助生殖技术
流产
Hypothyroidism
Autoimmune thyroid disease
Natural pregnancy
Artificial assisted repro duetion technique
Miscarriage
