摘要
目的分析幽门螺旋杆菌（HP）感染时血清及胃黏膜组织中白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF—α）的水平，探讨它们之间的关系。方法采用放射免疫法和酶联免疫吸附实验夹心法分别检测HP阳性患者在治疗前后血清和胃黏膜组织中的IL-8，TNF—α的水平。结果HP感染程度越严重者，胃黏膜组织中IL-8，TNF—α水平越高，各组间差异均有统计学显著性意义（P〈0．05）。HP根除后血清、胃黏膜组织中IL-8，TNF—α水平明显下降，与根除前相比差异有统计学意义（P〈0．05）。结论IL-8，TNF—α与HP感染密切相关，且参与了胃黏膜损伤的病理过程。
Objective To evaluate the relationgs between Helicobacter pylori （HP） infestation and IL-8 and TNF-α in serum and gastric mucosa. Methods Radio-immunity and ELISA sand with were used to detective IL-8 and TNF-α in HP infestation before and after eradication. Results The high extend of HP infestation,the more activity of IL-8 and TNF-α. There were great difference among them （P〈0. 05） . The level of IL-8 and TNF-α in serum and gastric mucosa were obviousely decreased in HP infestation before and after eradication（P〈0. 05）. Conclusion IL-8 and TNF-α are closely associated with HP infestation. They play a significant role in mucosal injury.
出处
《现代检验医学杂志》
CAS
2009年第1期90-92,共3页
Journal of Modern Laboratory Medicine
