摘要
目的研究中国北方地区呼吸道微生态学,了解该地区咽部正常微生物菌群生态平衡现状及咽炎患者咽部微生物菌群生态失平衡状况,探讨各种生态因子对咽部微生物定植的影响,确定北方地区慢性咽炎患者咽部菌群的组成及动态变化和北方地区人群不同季节咽部的优势菌种,为呼吸系统疾病的预防和治疗提供合理的指导方案。方法选择北方地区的城乡居民及农民、牧民,分为正常成年人、儿童、慢性咽炎患者、急性咽炎患者,按四季变化进行定位定性测定。共采集咽部标本570份。结果农牧民致病菌中肠道细菌导致的急性咽炎的比例较城镇居民要高,城镇居民中单身老人或单亲家庭的子女巴斯德菌感染多见;流感嗜血杆菌的感染比率在冬春季节偏高。结论咽炎的发生是由于咽部解剖生境发生了微生物的生态平衡失调,致病菌基本取代了原生境微生物群落,处于顶峰的微生物都是致病菌或原来处于冗余状态的、受正常顶峰的微生物抑制的条件致病菌群;应用抗生素可能造成某些菌群群抑制甚至可以出现生境裸露。
Objective The purposes of the research were to study the pathogens microbiology causing respiratory tract infection in Northern China; to understand the balance of normal pharyngeal flora and unbalance of pharyngitis flora in Northern China; to explore the effect of various ecological factors on pharyngeal microorganism colonization ; to determine the composition, dynamic and significant pathogens of pharyngeal flora in Northern China; to guide the prevention and treatment of respiratory diseases. Methods 570 pharyngeal samples were collected and qualitative analyzied from different groups, which includes persons （city residents, farmers and herdsmen） ;adults and children;chronic pharyngitis and acute pharyngitis. Results The results showed that acute pharyngitis caused by intestinal bacteria was higher proportion in population of farmers and herdsmen than city residents ; pasteur infection was more popular in the city single olds and single-parent children ; and higher haemophilus influenzae infection rate during Winter and Spring. Conclusions In conclusion, pharyngitis was caused by the unbalance of microorganism ecology and the pathogens was becoming significant in pharyngeal habitat, or the pharyngeal flora was inhibited by the antibiotics and appeared the habitat bareness.
出处
《中华临床医师杂志（电子版）》
CAS
2009年第1期36-41,共6页
Chinese Journal of Clinicians(Electronic Edition)
基金
内蒙古自治区自然科学基金资助项目(200508010906)
关键词
咽炎
微生物学
细菌
华北地区
Pharyngitis
Microbiology
Bacteria
NORTH CHINA
