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米力农治疗难治性心力衰竭112例临床疗效观察 被引量:20

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摘要 目的:观察米力农治疗顽固性心力衰竭的疗效及安全性。方法:将112例顽固性心力衰竭无心律失常患者随机分为两组,对照组给予常规强心、利尿、扩血管治疗;治疗组除常规治疗外给予米力农注射液(每支5 mg,山东鲁南制药厂生产)0.375μg.kg^-1.min^-1持续泵入,5 d为1个疗程。观察治疗前后症状、体征、血压、心率及心功能指标。结果:治疗组临床总有效率为91.07%,明显改善左室收缩功能障碍。在收缩压、舒张压、每搏量、每分输出量、左室射血分数及心功能改善方面与对照组比较差异有显著性。结论:米力农持续泵入治疗能有效改善顽固性心力衰竭患者的心功能。
作者 佘鲜花
出处 《临床医药实践》 2009年第1期42-43,共2页 Proceeding of Clinical Medicine
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参考文献7

  • 1Honerjager P. pharmacology of bipyridine phosphodi- esterase Ⅲ inhibitors [J]. Am Heart J, 1991, 121 (6pt2):1 939-1 944.
  • 2闫子星,马捷.小剂量单次静脉注射米力农对兔顿抑心肌血清cTnI的影响[J].中国医师杂志,2005,7(10):1307-1308. 被引量:9
  • 3Yamaura K,Okamoto H,Akiyoshi K,et al. Effect of low. dose milrinone on gastri intramueosal pH and systemic inflammation after hypothermic cardiopulmonary bypass[J]. J Cardiothorae Vase Anesh ,2001, 15(2) :197-203.
  • 4Sulek C A,Blas M L,I.obato E B. Milrinone increase milddle cerebral artery blood flow velocity after car- diopulmonary bypass [ J ]. J Cardiothorac Vasc Anesth, 2002,16 ( 1 ) : 64-69.
  • 5Mounoff T,Loiek H M ,VanAken H,et al. Milrinone modnlates endoto xemia systemic inflammation and subsequent alate phase response after cardiopulmonary bypass (CPB) [J]. Anesthesiology, 1999,90 (1) :72-80.
  • 6Cusik D A,Pfeifer P B,Leuigg R J. Effects of in travenons milrinone followed by titration of gigh-chose and vasodilator therapy on clinical outcome and rehospitalization rates in patients with severe heart failare[J]. Am J Cardiol,1998,82(9):1 060-1 065.
  • 7Hatziacharias A, Makris T, Krespi P,et al. Intermittent milrinone effect on long-term hemodynamic profile in patients with severe congestive heart failure [J]. Am Heart J,1999,138(2Pt1):241-246.

二级参考文献11

  • 1Rump AF, Blazincic B, Klaus W. Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts[J].J Arzneimittelforschung, 1993, 43: 1262-1266
  • 2Feneck RO. Effects of variable dose milrinone in patients with low cardiac output after cardiac surgery[J].J Am Heart, 1991, 121: 1995-1999
  • 3Haraldssons A, KiEler-Jensen N, Ricksten SE. The additive pulmonary vasodilatory effects of inhaled postacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension[J]. Anesth Analg, 2001,93 (6):1439-1455
  • 4Yamaura K,Okamoto H, Akiyoshi K, et al. Effect of low-dose milrinone on gastri intramucosal pH and systemic inflammation after hypothermic cardiopulmonary bypass[J].J Cardiothorac Vase Anesh,2001,15(2)197-203
  • 5Sulek CA,Blas ML,Lobato EB.Milrinone increase milddle cerebral artery blood flow velocity after cardiopulmonary bypass[J].J Cardiothorac Vasc Anesth, 2002, 16 (1);64-69
  • 6Kikura M,Sato S.The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting[J]. Anesth Aalg,2002,94(1):22-30
  • 7McDonough JL, Labugger R, Pickett W, et al. Cardiac troponin I is modified in the myocardium of bypass patients[J]. Circulation, 2001, 103: 58-64
  • 8Neagoe C, Kulke M, del Monte F,et al. Titin isoform switch in ischemic human heart disease[J]. Circulation,2002, 106: 1333-1341
  • 9Ritchie RH, Wuttke RD, Stafford I,et al. Relation between acute myocardial uptake and hemodynamic and electrocardiographic effects of metoprolol in humans[J]. J Cardiovasc Pharmacol, 1994,23:57-65
  • 10Nakano A, Baines CP, Kim SO, et al. Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK[J].J Circ Res, 2000, 86: 144-151

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