摘要
目的分别探讨蛋白激酶B(AKT)与端粒酶在非小细胞肺癌(NSCLC)中的表达。方法对40例NSCLC组织和20例正常肺组织行HE染色及AKT和端粒酶的免疫组化染色。结果NSCLC中AKT、端粒酶的阳性率分别为67.5%和77.5%,明显高于正常肺组织的2.5%和0%(P<0.05)。AKT的表达与肺癌的分化程度及吸烟状态有关(P<0.05)、但是与临床分期、淋巴结转移无显著相关(P>0.05)。端粒酶的表达与肺癌的分化程度及吸烟状态有显著的相关性(P<0.05)但与临床分期、淋巴结转移无相关性(P>0.05)。且AKT与端粒酶在肺癌中的表达有相关性。结论AKT,端粒酶在肺癌组织中的表达显著增高,并与肺癌的分化程度及患者的吸烟状态显著相关,并且两者在肺癌的表达中有显著相关性。
Objective To evaluate the association of Akt expression with telomerase expression and the relation. Methods The detection of AKT and telomerase expression by histochemistry in 40 NSCLC and 20 normal lung samples. Results Akt protein positively expressed in 67.5 % （27/40） samples, telomerase positively expressed in 77.5 % （31/40）. There were no statistically significant association between Akt protein （ and telomerase） expression and age, histology, or pathological stage （ P 〉 0.05 ）. But there were statistically significant association between Akt protein （and telomerase） expression and differentiation, smoking status （P 〈 0. 05 ）. Spearman correlation analysis shew association of positive Akt protein with telomerase expression （ P 〈 0. 05 ）. Conclusion In NSCLC patients, positive Akt and telomerase expression correlate with differentiation, smoking status but have no relation with other clinicopathological features.
出处
《临床肺科杂志》
2009年第3期342-343,共2页
Journal of Clinical Pulmonary Medicine
关键词
非小细胞肺癌
AKT
端粒酶
临床病理特征
Akt
telomerase
non-small cell lung cancer
clinicopathological features
