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胰腺癌组织中骨桥蛋白与血管内皮生长因子的表达及其临床意义 被引量：1

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摘要 胰腺癌是预后较差的恶性肿瘤之一．5年生存率不足5％。其主要因素在于胰腺癌早期诊断率较低且易转移；约半数患者确诊时已发生转移．而丧失手术机会^[1]。骨桥蛋白（osteopontin，OPN）是一类分泌型的糖基化磷蛋白，其在结直肠癌、胃癌等多种恶性肿瘤的原发肿瘤及其转移瘤组织中呈高表达^[2]。以往研究表明．血管内皮生长因子（vascular endothelial growth factor．VEGF）可有效促进肿瘤新生血管的形成．与肿瘤生长、浸润和转移密切相关口一。
作者 胡俊毅 刘瑞 经纬
机构地区 上海长海医院外科
出处 《中华消化杂志》 CAS CSCD 北大核心 2009年第1期54-55,共2页 Chinese Journal of Digestion
关键词 血管内皮生长因子 胰腺癌组织 骨桥蛋白 临床意义 浸润和转移 肿瘤新生血管 恶性肿瘤 5年生存率
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献6

  • 1Koopmann J, Fedarko NS, Jain A, et al. Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prey, 2004, 13: 487-491.
  • 2Rangaswami H, Bulbule A, Kundu GC. Osteopontin; role in cell signaling and cancer progression. Trends Cell Biol, 2006, 16: 79-87.
  • 3Choi WW, Lewis MM, Lawson D, et al. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF family gene expression. Mod Pathol,2005,18: 143-152.
  • 4孙现军,左文述,马恒,侯文红,蔡淑萍,姜希宏.骨桥蛋白mRNA在胃癌中的表达及其临床意义[J].中华肿瘤杂志,2005,27(5):292-295. 被引量：19
  • 5Nakamura Y,Yasuoka H,Tsujimoto M,et al. Importance of lymph vessels in gastric cancer: a prognostic indicator in general and predictor for lymph node metastasis in early stage cancer. J ClinPathol, 2006,59: 77-82.
  • 6Chakraborty G, Jain S, Kundu GC. Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms. Cancer Res, 2008, 68: 152-161.

二级参考文献17

  • 1Oates A J, Barraelough R, Rudland PS. The role of osteopontin in tumorigenesis and metastasis. Invasion Metastasis, 1997,17:1-15.
  • 2Rudland PS, Higgins AP, Tanani ME, et al. Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer. Cancer Res, 2002,62 : 3417-3427.
  • 3Craig AM, Bowden GT, Chambers AF, et al. Secreted phosphoprotein mRNA is induced during multi-stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts. Int J Cancer, 1990,46:133-137.
  • 4Behrend El, Craig AM, Wilson SM, et al. Reduced malignancy of ras-transformed NIH3T3 cells expressing antisense osteopontin RNA. Cancer Res, 1994,54 : 832-837.
  • 5Chomczynski P, Sacchi N. Single-Step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem,1987, 162:156-159.
  • 6Bayless KJ, Davis GE. Identification of dual alpha 4betal integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin. J Biol Chem, 2001,276: 13483-13489.
  • 7McDevitt TC, Nelson KE, Stayton PS. Constrained cell recognition peptides engineered into streptavidin. Biotechnol Prog, 1999, 15:391-396.
  • 8Yokosaki Y, Matsuura N,Sasaki T,et al. The integrin alpha(9)beta(1) binds to a novel recognition sequece(SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem, 1999,274:36328-36334.
  • 9Tuck AB, O' Malley FP, Singhal H, et al. Osteopontin expression in a group of lymph node negative breast cancer patients, Int J Cancer,1998,79 : 502-508.
  • 10Teruyoshi UE, Yokozaki H, Kitadai Y, et al. Co-Expression of osteopontin and CD44v9 in gastric cancer. Int J Cancer, 1998,79:127-132.

共引文献18

同被引文献11

引证文献1

二级引证文献6

中华消化杂志
2009年 第1期

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