摘要
目的探讨子痫前期及子痫患者血小板膜糖蛋白Ⅱb/Ⅲa(GPⅡb/Ⅲa)的水平变化及其与肾功能异常的相关性。方法分别采用流式细胞术和全自动生化分析仪,检测子痫前期及子痫患者、正常孕晚期、正常未孕妇女血中GPⅡb/Ⅲa水平和肾功能相关指标(BUN、CREA、UA)。结果重度子痫前期-子痫组GPⅡb/Ⅲa水平明显升高,同时伴有BUN、CREA、UA水平升高,与正常孕晚期组、轻度子痫前期组比较,差异均有统计学意义。结论子痫前期及子痫患者GPⅡb/Ⅲa水平升高可引起肾小球小血管内血小板活化、黏附及聚集,进而影响其肾功能。
Objective To explore the relationship of membrane glycoprotein （GP） Ⅱb/Ⅲ a level in platelets of patients with pre-eclampsia and eclampsia to renal disfunction. Methods Twenty-two patients with mild pre-eclampsia, 28 with severe preeelampsia, 10 with eclampsia as well as 30 healthy pregnant women and 20 healthy unpregnant women were determined for GP Ⅱ b / Ⅲa by flow cytometry and for urea nigrogen （BUN）, ereatinine （CREA） as well as uric acid （UA） by full-automatic biochemical analyzer, and the results were compared. Results The GP Ⅱb /Ⅲ a, BUN, CREA and UA levels of patients with severe pre-eclampsia and eclampsia were significantly higher than those of healthy pregnant women and the patients with mild pre-eclampsia. Conclusion The increases of GP Ⅱb /Ⅲa levels in patients with pre-eclampsia and eclampsia may result in the activation, adhesion and aggregation of platelet in small vessels of renal glomerulus, thus influence the renal function.
出处
《中国生物制品学杂志》
CAS
CSCD
2009年第2期183-184,195,共3页
Chinese Journal of Biologicals
基金
长春科技局资助项目(08SF44)
关键词
子痫前期
子痫
血小板
糖蛋白
肾功能
Pre-eclampsia
Eclampsia
Platelet
Glycoprotein
Renal function
