摘要
目的观察木豆叶对卵巢切除大鼠血管内皮细胞功能的影响。方法采用双侧卵巢摘除法诱导骨质疏松症模型，术后3d开始防治性给药，于第9w眼球采血，放射免疫法检测内皮素，硝酸还原酶法检测一氧化氮。结果血浆ET水平升高，血清NO含量降低，与假手术组比较有统计学意义（P〈0．01）；龙牡壮骨颗粒组、木豆叶高、中、低剂组都不同程度降低ET水平，增加NO含量，与模型组比较有统计学意义（P〈0．01或P〈0．05）。结论木豆叶通过调节ET、NO的含量提高去势大鼠血管内皮功能。
Objective To observe the effects of Cajanus Cajan（ L. ） Millsp on vascular endothelial function of ovariectomized rats. Methods Established the rat models with osteoporosis by ovariectomy in the experiments. Treated the experimental rats with drugs for 8 weeks, then managed the rats blood sampling from eye sockets. According to radioimmunoassay （RIA）and the nitrate reductase follows measured ET and NO respectively. Results In model group the level of ET in plasma promoted markedly and the content of NO in serum decreased noticeably, compared with normal group. While the level of ET in plasma was low greatly and the content of NO in serum was high enough in Cajanus Cajan（L. ） Millsp high, middle, and low dose groups, compared with model group. Conclusion CajanusCajan（L. ） Millsp can regulate vascular endothelial function of the ovariectomized rats through impacting on ET and NO.
出处
《中国骨质疏松杂志》
CAS
CSCD
2009年第2期142-145,152,共5页
Chinese Journal of Osteoporosis
关键词
木豆叶
内皮素
一氧化氮
血管内皮细胞功能
Cajanus Cajan（L. ） Millsp
Nitric oxide
Endothelin
Vascular endothelial function
