摘要
目的探讨抗α-胞衬蛋白(Fodrin)抗体在干燥综合征(SS)诊断及病情判断中的作用。方法应用酶联免疫吸附试验(ELISA)检测40例原发性SS(pSS)、24例继发性SS(sSS)、32例其他结缔组织病(CTD)和31例非CTD患者血清抗α-Fodrin-IgA、IgG抗体,同时记录SS患者的临床资料。结果抗α-Fodrin-IgA、IgG抗体诊断SS的敏感性分别为31.3%、28.1%,特异性分别为90.5%、88.9%;同时检测两型抗体诊断SS的敏感性显著提高,达48.4%(P<0.05)。pSS和sSS患者抗α-Fodrin抗体(Ⅰ型或Ⅱ型)的阳性率均显著高于非CTD组(P<0.05);SS患者抗α-Fodrin抗体的出现与临床症状、眼部体征及核素检查显示的唾液腺功能受损无明显相关性(P>0.05);抗α-Fodrin抗体阳性患者血清C反应蛋白高于阴性者(P<0.05);抗核抗体(ANA)、抗SSA(干燥综合征抗原A)、抗SSB(干燥综合征抗原B)抗体3项阴性的患者抗α-Fodrin抗体阳性率为36.4%。结论抗α-Fodrin抗体特异性较好,对诊断SS有一定参考价值,尤其对于ANA、抗SSA、抗SSB抗体阴性的患者,且可能有助于评估SS病情活动性。
Objective To explore the significance of anti-α-Fodrin antibody in the diagnosis and assessment of Sjogren＇s syndrome（SS）. Methods Serum anti-α-Fodrin IgA and lgG antibody of patients with primary SS （ pSS, n = 40） , secondary SS（ sSS, n = 24） , other connective tissue diseases （ CTD, n = 32） , and non-CTD （ n = 31 ） were detected by enzyme-linked immunosorbent assay （ELISA）. Results The specificities of anti-α- Fodrin IgA and IgG antibody for SS were 90. 5% and 88.9% , and the sensitivities were 31.3% and 28.1% respectively. The positive rate of anti-α-Fodrin IgA and（or） IgG antibody in patients with pSS or sSS was significantly higher than that in non-CTD persons（ P 〈 0.05 ）. The presence of anti-α-Fodrin antibody had no significant correlation with clinical manifestation, ophthalmic signs and salivary function, but the level of serum C reactive protein was higher in patients with positive anti-α-Fodrin antibodies （ P 〈 0. 05 ）. Anti-α-Fodrin anti-bodies were present in 36. 4% of SS patients with negative anti-nucleus antibody（ANA）, anti-SSA and anti- SSB antibody. Condusions As a new diagnostic marker for patients with SS, anti-α-Fodrin antibody had high specificity. It is helpful for the diagnosis of SS especially for patient with negative ANA, anti-SSA and anti-SSB antibody.
出处
《国际内科学杂志》
CAS
2009年第1期5-8,共4页
International Journal of Internal Medicine
