摘要
目的:探讨不同抗栓药物对阵发性非瓣膜性心房颤动(Paroxysmal nonvalvul aratrial fibrillation,PAF)心、脑及外周血管疾病血栓的预防作用。方法:选取PAF病例807例,其中80例因各种原因失访,有效病例727例,分别使用华法林和阿司匹林进行抗栓治疗,随访心脑血管疾病发生情况,比较二者预防主要终点、次要终点事件、主要出血事件及次要出血事件发生率。结果:高危PAF组,使用华法林治疗主要终点事件及次要终点事件均较阿司匹林组低(P﹤0.05),出血事件二者间无差异(P>0.05);中危PAF组,使用华法林及阿司匹林治疗,二者在主要终点事件及出血事件发生率间无差异(P>0.05),而应用华法林抗凝较应用阿司匹林抗栓能降低次要终点事件、及次要事件(P﹤0.05)。结论:对高危PAF病例,应用华法林抗凝较优于应用阿司匹林抗栓;对中危PAF病例,主要事件二者疗效相当,但应用华法林抗凝能减低次要事件发生率。
Objective：To explorer the effect of aspirin and warfarin on prevention thrombus of paroxysmal nonvalvular atrial fibrillation （PAF）. Methods：Eight hundred and seven patients with PAF were investigated, and divided into four groups. Patients were treated by Aspirin or warfarin, main destination events, secondary destination events, main bleeding events and secondary bleeding events were observed and compared. Results：Compared Aspirin group, on main destination events and secondary destination events were lower in patients with higher of risk PAF（P 〈 0.05）, but there were no difference on main bleeding events and secondary bleeding events（P 〉 0.05）. Three were no different on main destination events and secondary destination events between group Aspirin and warfarin in moderate risk of PAF patients（P 〉 0.05） ,but warfarin could lower secondary destination events and total events compared with Aspirin （P 〈 0.05）. Conclusion： On PAF patients with higher stoke, warfarin on preventing thrombus superiored aspirin. On PAF patients with medium stoke, there were no difference between warfarin and aspirin on main events and bleeding events, but patients treated by warfarin can reduce secondary destination events.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第2期218-222,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
无锡市科技局基金资助(CSZ00735)
关键词
心房颤动
抗栓
阵发性
atrial fibrillation
prevention thrombus
paroxysmal
