摘要
目的探讨左卡尼汀在维持性血液透析(HD)患者中的治疗作用。方法65例维持性血液透析患者随机分成治疗组和对照组,治疗组患者在每次透析结束后静脉注射左卡尼订1.0g,每周3次,治疗3个月,对照组注射生理盐水。结果治疗组患者的食欲、心律失常、透析中的肌痉挛和低血压等症状的改善率明显高于对照组(P<0.01),治疗组患者的血红蛋白、血浆总蛋白、白蛋白、转铁蛋白和红细胞压积比对照组显著升高(P<0.05)。结论维持性血液透析患者静脉补充左卡尼汀可明显改善患者的营养不良状况,纠正贫血,降低透析中的肌痉挛和低血压的发生率,不良反应轻微、安全可靠。
Objective To investigate the clinical effects of L-carnitine supplemention in maintenance hemodialysis patients. Methods 65 maintenance hemodialysis patients were randomly divided into two groups ： control group （n = 32） and treatment group （n = 33）. In treatment group, lg L-carnitine was infused to the patients at the end of each dialysis treatment for 3 months,while normal saline was given in the control group. Results Compared with control group,the treatment group showed a statistically significant decrease in fatigue,lethargy,muscular weakness, dialysis-related hypotension and cramps （P 〈 0.01 ）, and increased blood, hemoglobin, serum total protein, album in transferrin （P 〈 0.05）. Conclusion Intravenous L-carnitine supplementation to maintenance henmodialysis patients safely and effectively improves protein-energy malnutrition, correct anaemia, and decrease the incidence of dialysis-related hypotension and recurrent cramps side effects of intravenous L-carritine supplementation.
出处
《中国现代医生》
2009年第3期94-95,共2页
China Modern Doctor
