摘要
目的比较长沙市入园儿童(4～6岁)平衡营养与营养素缺乏状况对乙肝疫苗免疫远期效果的影响,探讨提高乙肝疫苗免疫远期效果的科学方法。方法采用随机整群抽样方法调查215名儿童,统计乙肝疫苗基础免疫、加强免疫接种率;乙肝抗体检测结果;微营养素缺乏、常见疾病等相关信息。结果本次调查儿童基础乙肝疫苗接种率达100%;儿童乙肝疫苗基础免疫3年后抗-HBs阳性率平均为43.7%,其中男孩43.8%,女孩43.7%;有微营养素缺乏症儿童抗体阳性率28.9%;营养状况较好儿童抗体阳性率46.9%。结论结果表明本次调查对象儿童完成乙肝疫苗基础免疫3年后抗-HBs阳性率降低;其中微营养素缺乏儿童抗-HBs阳性率与正常儿童比较有显著差异;针对影响乙肝免疫远期效果的原因,作者认为对入园儿童适时进行乙肝抗体监测,采取乙肝疫苗加强免疫、改善儿童营养状况和减少疾病等,均可提高乙肝疫苗免疫的远期效果。
Objective To compare the influence of children （aged 4-6 years） of well - balanced nutrition with those of nutrition deficiency on the long term immune effect with hepatitis B vaccine inoculation in Changsha, and to explore the possible scientific means for promoting the permanent immune effect of Hepatitis B vaccine （HBv）. Methods With random cluster sampling, 215 children were selected to investigate the basic immunization rate and the intensified immunization rate of HBv, test the result of Hepatitis B antibody, and find out if there is micronutrient deficiency and other common diseases or not. Results The coverage rate of HBv was 100% in these Children. The average anti - HBs positive rate of children after three years HBv inoculation was 43.7%, with boys of 43.8% and girls of 43.7% ; and that of children of micronutrient deficiency was 28.9 %, children of better nutrition 46.9 %. Conclusions The anti - HBs positive rate is lower in the children received HBv after three years, and that of the children of micronutrient deficiency is lower than the normal children, and there is a significant difference between them. Therefore, it is believed by the author that enhancing nutrition, increasing the opportunity of reinforcement immunization and monitoring the anti - HBs for preschool children in time can improve the longterm immune effect of HBv.
出处
《实用预防医学》
CAS
2009年第1期99-101,共3页
Practical Preventive Medicine
关键词
乙肝疫苗
免疫预防
远期效果
营养改善
加强免疫
Hepatitis B vaccine（HBv）
Immunization
Long - term immune effect
Nutrition improvement
Reinforcement immunization
