摘要
背景:Survivin是一个双功能蛋白,能抑制凋亡和调节细胞分化它参与了胃癌侵袭和/或转移的发生和发展。Survivin启动子C-31G多态性能抑制survvin基因细胞循环依赖性转录,导致survivin mRNA和蛋白的过表达。目的:本实验研究survivin C-31G多态性是否能影响胃癌的发病风险。方法:作中国人群的病例对照研究,用PCR-RFLP方法研究了survivin C-31G多态性和胃癌风险的相关性。结果:此多态性的分布在病例组和对照组没有差异。变异基因型和胃癌风险之间也没有统计学的相关性。然而,变异基因型(GG+GC)和远端、高分化或周围淋巴无转移的胃癌有相关性。结论:结果提示在中国人群survivin C-31G多态性可能和远端胃的癌变,以及肿瘤的分化和进展相关。
Background： Survivin is a bifunctional protein that inhibits apoptosis and regulates cell division. Its expression may maintain mucosal integrity in normal gastric mucosa, hut result in cancer progression in cancer tissues. The C-31 G polymorphism in the survivin promoter could derepress the cell cycle-dependent transcription of the human survivin gene, resulting in over-expression of survivin at both mRNA and protein levels. This survivin mutation has only been clinically studied on cervical careinoma. However, no study has ever been conducted to evaluate the effect of the polymorphism on other cancers, including gastric cancer. Purpose and Methods： In this hospital-based, case-control study, we investigated the association between the survivin C-31G polymorphism and risk of gastric cancer in Chinese population using PCR-RFLP protocols. Results： The distribution of survivin-31 genotype was similar between eases and controls （ P =0. 35 ）. No statistically significant association was observed between gastric cancer risk and the variant genotype （ GG ＋ GC）. However, the variant genotype （GG ＋ GC） was either associated with risk of distal gastric cancer （adjusted OR =0.50, 95% CI = 0.30-0.83 ） or with risk of well-differentiated tumor （ adjusted OR = 0.46, 95% CI = 0.22-0.97 ）. Conclusion： Our results firstly demonstrated that the survivin C-31 G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in Chinese population.
出处
《药学与临床研究》
2009年第1期9-13,共5页
Pharmaceutical and Clinical Research
