摘要
目的:探讨糖尿病视网膜病变(diabetic retinopathy,DR)患者血浆内皮素1(endothelin-1,ET-1)、降钙素基因相关肽(calcium gene related peptide,CGRP)的水平变化,以阐明其在糖尿病并发视网膜病变中的作用。方法:应用放射免疫分析(RIA)检测123例DR患者和157例对照组(未并发DR)患者血浆ET-1,CGRP的浓度。结果:病例组的患者的血浆ET-1(186.2±44.0ng/L),CGRP(46.4±13.3ng/L)与对照组(135.3±28.1ng/L)和(73.2±19.6ng/L)相比较,差异均有显著性意义(P<0.01)。而非增殖型与增殖型患者对照比较亦有显著性差异(P<0.05)。增殖型患者血浆ET-1,CGRP水平呈负相关(r=-0.679,P<0.05)。结论:ET-1和CGRP在DR发病过程中可能有着重要的病理作用,并且与DR病变严重程度有着一定的关联,血浆含量检测有助于判断病情的程度。
AIM ： To illustrate the effects of endothelin-1 （ ET-1 ） and calcitonin gene related peptide （CGRP） in patients with diabetic retinopathy （DR） through investigation of the changes of the plasma levels of ET-1 and CGRP.
METHODS： Plasma ET-1 and CGRP concentrations were measured with RIA in 123 patients with DR and 157 controls.
RESULTS： Plasma ET-1（186.2±44.0ng/L） and CGRP （46.4 ±13.3ng/L） levels in the patients with DR were significantly different from those in the controls （ET-1： 135.3±28.1ng/L, CGRP： 73.3 ± 19.6ng/L, P〈0.01）. Differences between the levels of these non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were also significant （ P 〈 0. 05）. In patients with proliferative diabetic retinopathy, the plasma ET-1 levels were negtively correlated to the plasma CGRP levels （r= -0.679, P〈O.05）.
CONCLUSION： Plasma ET-1 and CGRP play important role in the whole patho-physiologic process of DR and correlate to the severity of the disease, measuements of their plasma concentrations help to predict theseverity of the disease.
出处
《国际眼科杂志》
CAS
2009年第2期309-310,共2页
International Eye Science
基金
中国上海市嘉定区卫生局科研基金(No.KYXM-2006-11-04)~~
