摘要
目的探讨醒脑通脉颗粒对急性脑梗死的神经保护作用。方法采用线栓法制作大鼠局灶性脑缺血再灌注模型,检测各缺血区的TNF-a、IL-1β、IL-6和IL-8的含量,评价醒脑通脉颗粒及尼莫地平的干预作用。结果醒脑通脉颗粒小剂量(250mg/kg)、大剂量(1000mg/kg)组均能降低脑组织中TNF-a及IL-1β、IL-6和IL-8等炎性细胞因子的含量(P<0.05,P<0.01),较尼莫地平为优。结论醒脑通脉颗粒对大鼠局灶性脑缺血再灌注损伤有保护作用(以大剂量组为优),其作用机制与降低TNF-a和炎性细胞因子的含量有关。
Objective To observe the neural system protection of Xingnaotongmai capsule for acute cerebral infarct in rats. Methods The focal cerebral ischemic reperfusion injury model was established with thread embolism of middle cerebral artery. The content of TNF-a, IL-1β, IL-6 and IL-8 in ischemic area were detected. Results Both low dosage （250mg/kg） and high dosage （1000mg/kg） of Xingnaotongmai capsule treatment reduced the content of TNF-a, IL-1β, II-6 and IL-8 in the rat＇s brain （P〈0. 01,P〈0.05）,the effects were better than nimodipine. Conclusion Xingnaotongmai capsule can protect cerebral ischemic reperfusion injury in rats.
出处
《精神医学杂志》
2009年第1期11-13,共3页
Journal of Psychiatry
基金
广西研究生教育创新计划资助项目
No:2007106001005M04
关键词
醒脑通脉颗粒
脑缺血
再灌注损伤
肿瘤坏死因子
炎性细胞因子
Xingnaotongmai capsule Cerebral infarct Cerebral ischemic reperfusion injury TNF-a Inflammatory cytokine
