摘要
[目的]研究肿节风挥发油(SGE)对环磷酰胺(CTX)治疗H22、S180小鼠的增效和减毒作用。[方法]建立小鼠体内移植性肉瘤、肝癌模型,通过两种给药途径,观察肿节风挥发油与环磷酰胺联合用药对荷瘤小鼠抑瘤率的影响;观察SGE拮抗CTX引起血小板、白细胞及血红蛋白下降。[结果]肿节风挥发油与CTX合用时,对肝癌H22、肉瘤S180两种肿瘤均有不同程度的抑瘤增效作用。CTX(10mg/kg或15mg/kg)分别联用iv.SGE(36.6mg/kg),对小鼠H22、S180的抑瘤率均高于相应剂量的单用CTX(P<0.05);CTX(20mg/kg)联用ig.SGE(73.2mg/kg),对H22的抑瘤率高于单用CTX(P<0.05)。肿节风挥发油能明显拮抗CTX引起的血小板、白细胞下降(P<0.05～0.01)。[结论]肿节风挥发油能增强CTX的抗肿瘤作用,同时减轻CTX的毒性。
[Objective] To study synergistic effect and decreasing toxicity of Sarcandra Glabra essential oils （SGE） on H22 and S180 bearing mice treated with cytoxan （CTX）. [Method] Transplanting H22 and S180 mice tumor models were established to observe the tumor inhibiting rate when SGE was used in combination with CTX by two different routes of administration. While the inhibition effects of SGE in decreasing blood platelet, leukocyte and hemoglobin induced by CTX were also detected. [Result] SGE has anti-tumor and synergy effect when combined with CTX on H22 and S180 bearing mice. The H22 and S180 tumor inhibiting rates of CTX （10mg .kg^-1 or 15mg.kg^-1 ） combined with SGE （36.6mg.kg^-1 ） by iv. were increased compared with using CTX alone （P 〈0.05）. While administrated by ig. , the H22 tumor inhibiting rate of CTX （20mg.kg^-1 ） combined with SGE （73.2mg.kg^-1 ） ean also be improved compared with CTX alone （P〈0.05）. SGE could obviously inhibit the descent of platelet, leukocyte induced by CTX （P〈0.05）. [Conclusion] Sareandra Glabra essential Oil can enhance anti-tumor effects and reduce toxicity of CTX.
出处
《浙江中医药大学学报》
CAS
2009年第1期116-118,共3页
Journal of Zhejiang Chinese Medical University
基金
浙江省重大科技攻关项目(No:2004C13009)~~
关键词
肿节风挥发油
环磷酰胺
增效
减毒
Sarcandra Glabra extracts
CTX
synergistic
toxicity reduction
