摘要
[目的]观察白及甘露聚糖的抗炎、镇痛及抗实验性胃溃疡作用。[方法]从白及中分离白及甘露聚糖。采用二甲苯诱导小鼠耳廓肿胀法、小鼠毛细血管通透性进行抗炎试验;采用小鼠醋酸扭体法、热板法进行镇痛实验观察;采用冷水应激、幽门结扎等方法进行胃溃疡试验。[结果]白及甘露聚糖对小鼠耳廓肿胀有明显对抗作用;对小鼠毛细血管通透性有一定对抗作用;白及甘露聚糖能明显抑制热板和醋酸所致小鼠疼痛,减少热板引起的小鼠疼痛反应和减少扭体次数。大鼠幽门结扎实验显示,白及甘露聚糖(3mg/只)能有效降低溃疡指数(P<0.05);大鼠应激性溃疡实验显示,白及甘露聚糖(3mg/只)能有效降低溃疡指数(P<0.01)。[结论]:白及甘露聚糖具有良好抗炎和一定镇痛作用及对实验性胃溃疡有较好治疗作用。
[Objective]To observe the Baiji Manna Polysaccharide＇ s anti-gastric ulcer,anti-inflammation and abirritation. [Method] Separate Baiji Manna Polysaccharide from Baiji;take xylene to induce mice auricle swelling method and capillary permeability for anti-inflammation test; take mice acetate twisting method and hot board method for abirritation study; take cool water stimulant and pylori ligation for gastric ulcer test. [Result]Baiji Manna Polysaccharide has marked resistance to mice auricle swelling;definite re sistance to mice capillary permeability; can markedly inhibit mice pain caused by hot board and acetate, reduce pain reaction and twisting times induced by hot board. Rats pylori ligation test shows that Baiji Manna Polysaccharide（3mg/one） can effectively reduce ulcer index（P〈0.05） ;so does rats stress ulcer test（P〈0.01）. [Conclusion]Baiji Manna Polysaccharide has good anti-inflammation and definite abirritation,and good cure effect on gastric ulcer.
出处
《浙江中医药大学学报》
CAS
2009年第1期119-121,共3页
Journal of Zhejiang Chinese Medical University
关键词
白及甘露聚糖
抗炎
镇痛
胃溃疡
Baiji Manna Polysaccharide
anti-inflammation
abirritation
gastric ulcer
