期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抑制视网膜新生血管药物的研究进展 被引量：3

Development of medical research for the inhibition of retinal neovascularization
下载PDF
导出
摘要 视网膜新生血管存在于多种常见眼病的发展过程中,其发生及发展对眼的视功能有极大的威胁。药物抑制视网膜新生血管有助于对此类疾病的治疗。文中对研究视网膜新生血管的动物模型及药物研究进展作一综述。 Retinal neovascularization is a phenomenon observed in various kinds of eye diseases and it can threaten the visual function of patients. Medical treatment to inhibit retinal neovascularization will give them effective help. This article reviewed animal models of retinal neovascularization and researching development of medicine in this field.
作者 薛春燕 黄振平
机构地区 南京军区南京总医院眼科
出处 《医学研究生学报》 CAS 2009年第2期221-224,共4页 Journal of Medical Postgraduates
基金 南京军区医药卫生科研基金课题(批准号:07M086)
关键词 新生血管 视网膜 药物 动物模型 Neovascularization Retina Medicine Animal model
分类号 R774.1 [医药卫生—眼科]
  • 相关文献

参考文献22

  • 1Smith LE, Wesolowski E, Mclllan A, et al. Oxygen-induced retinopathy in the mouse[ J]. Invest Ophthalmol Vis Sci, 1994,35 (1) :101-111.
  • 2薛春燕,黄振平,金洁.小鼠视网膜新生血管模型的简易制备[J].医学研究生学报,2007,20(3):257-258. 被引量：7
  • 3Zhang D, Kaufman PL, Gao G, et al. intravitreal injection of plasicgen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats[J]. Diabetologia,2001,44(6) :757-765.
  • 4Olga D, Luz MR, Sylvain C, et al. Evidence for a brief period of enhanced oxygen susceptibility in the rat model of oxygen-induced retinopathy [ J ]. Invest Ophthahnol Vis Sci, 2002,43 ( 7 ) : 2481 - 2490 .
  • 5Bullard LE, Qi X, Penn JS. Role for extracellular signal-responsive kinase-1 and - 2 in retinal angiogenesis[ J]. Invest Ophthalmol Vis Sci, 2003,44(4) : 1722-1731.
  • 6Begum N, Ragolia L, Rienzie J, et al. Regulation of mitogenactivated protein in kinase phosphatase-1 induction by insulin in vascular smooth muscle cells. Evaluation of the role of the nitric oxide signaling pathway and protential defects in hypertension [J]. J Biol Chem,1998,273(39) :25164-25170.
  • 7Lawnicka H, Stepien H, Wyczolkowska J ,et al. Effect of somatostatin and octreotide on proliferation and vascular endothelial growth factor secretion from murine endothelial cell line (HECa10) culture[J]. Biochem Biophys Res Commun, 2000, 268 (2) :567-571.
  • 8Miller JW, Stinson WG, Folkman J. Regression of experimental iris neovascularization with systemic alpha-interferon [ J ]. Ophthalmology, 1995,100 ( 1 ) :9-14.
  • 9O' Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth[ J ]. Cell, 1997, 88(2) :277-285.
  • 10Le Gat L, Gogat K, Bouquet C, et al. In vivo adenovirus-mediated delivery of a uPA/uPAR antagonist reduces retinal neovascularization in a mouse model of retinopathy[ J]. Gene Ther, 2003, 10 (25) :2098-2103.

二级参考文献29

  • 1王理理,王毅,施宇华.视盘周围视网膜下出血[J].医学研究生学报,2005,18(12):1108-1109. 被引量：2
  • 2狄红杰,赵明,王扬天.糖尿病大鼠视网膜病变核因子-κB表达水平的研究[J].医学研究生学报,2006,19(4):341-343. 被引量：8
  • 3Kowluru RA,Koppolu P,Chakrabarti S,et al.Diabetes-induced activation of nuclear transcriptional factor in the retina,and its inhibition by antioxidants[J].Free Radic Res,2003,37(11):1169-1180.
  • 4Giulio R,Liu WH,Veronica A,et al.Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes[J].Diabetes,2002,51(7):2241-2248.
  • 5Poulaki V,Joussen AM,Mitsiades N,et al.The Role of IGF-I in the Pathogenesis of Diabetic Retinopathy.Invest.Ophthalmol[J].Vis Sci,2002,43(1):2966-2968.
  • 6Marina M,Stefania A,Barbara I,et al.Leukocyte-endothelial Interaction Is Augmented by High Glucose Concentrations and Hyperglycemia in a NF-kB-dependent Fashion[J].J Clin Invest,1998,101(9):1905-1915.
  • 7Mamputu JC,Renier G.Advanced glycation end-products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor-induced ICAM-1 expression:inhibitory effect of antioxidants[J].J Leukoc Biol,2004,75(6):1062-1069.
  • 8Joussen AM,Murata T,Tsujikawa A,et al.Leukocyte-mediated endothelial cell injury and death in the diabetic retina[J].Am J Pathol,2001,158(1):147-152.
  • 9Moore TCB,Moore JE,Kaji Y,et al.The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis[J].Invest Ophthalmol Vis Sci,2003,44(10):4457-4464.
  • 10Chen S,Mukherjee S,Chakraborty C,et al.High glucose-induced,endothelin-dependent,extracellular matrix protein synthesis is mediated via nuclear factor-κB and AP-1[J].Am J Physiol Cell Physiol,2003,284(2):C263-C272.

共引文献15

同被引文献24

  • 1田农,黄振平,王理理,王毅.玻璃体视网膜手术治疗高度近视性黄斑裂孔视网膜脱离[J].医学研究生学报,2005,18(5):424-426. 被引量：9
  • 2田超伟,朱琦,王雨生,郭长梅.巩膜外加压术治疗陈旧性视网膜脱离[J].中华眼底病杂志,2006,22(1):35-38. 被引量：19
  • 3王少华,黄振平,田农,陈穗桦.眼内直视下巩膜外冷凝视网膜裂孔[J].医学研究生学报,2007,20(3):281-282. 被引量：2
  • 4Morel C,Metge F.Acute retinal necrosis:clinical resentation,treatment and prognosis in a series of 22 patients[J].J Fr Ophthamol,2004,27(1):7-13.
  • 5Lau CH,Missotten T,Salzmann J,et al.Acute retinal necrosis Features,management and outcomes[J].Ophthalmology,2007,114(4):756-762.
  • 6Stephen GS,Harry WF Jr.Pars plana vitrectomy for primaryrhegmatogenous retinal detachment. Clini Ophthalmol . 2008
  • 7Saw SM,Gazzard G,Ajeet M,et al.An evidence-based analysisof surgical interventions for uncomplicated rhegmatogenous retinaldetachment. Acta Ophthalmologica Scandinavica . 2006
  • 8Shelley D,Daniel SG,Prithvi M,et al.One-year outcomes afterretinal detachment surgery among medicare beneficiaries. American Journal of Ophthalmology . 2010
  • 9Benson SE,Schlottmann PG,Bunce C,et al.Optical coherencetomography analysis of the macula after scleral buckle surgery forretinal detachment. Ophthalmology . 2007
  • 10Yi Yao M,Li Jiang M Ph Zhi-jun Wang MD and Mao-nian Zhang MD.Scleral Buckling Procedures for Longstanding or Chronic Rhegmatogenous Retinal Detachment with Subretinal Proliferation. Ophthalmology . 2006

引证文献3

二级引证文献10

医学研究生学报
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部