摘要
核因子-κB是一类广泛存在的多向转录调节作用的核蛋白因子,具有广泛的生物学作用。核因子-κB活化是多种肺疾病病理过程的早期关键步骤,活化后参与许多基因的转录调控,在感染、炎症反应、氧化应激、凋亡等过程中发挥重要作用。本文综述了核因子-κB在肺疾病中的作用。
Nuclear factor-κB is a protein family of multi-transcription regulators in various tissues and cells. It has many biological activities. NF-κB Activation seems to be a key to early event in the pathogenesis of many pulmonary diseases. Once NF-κB is activi- tated, it plays an important role in transcribing proinflammatory genes related with infections, inflammation, oxidative stress and apoptosis. The roles of NF-κB in pulmonary diseases was reviewed in this study.
出处
《现代生物医学进展》
CAS
2009年第3期552-554,共3页
Progress in Modern Biomedicine
基金
云南省自然科学基金(2003C0052M)
关键词
核因子-ΚB
炎症反应
肺疾病
Nuclear factor-κB
Inflammation
Pulmonary diseases
