摘要
目的分析维甲酸治疗儿童早幼粒白血病初期血液学变化及意义。方法用维甲酸+三氧化二砷(As2O3)+化疗治疗32例儿童早幼粒白血病,观察治疗初期白细胞、血小板、诱导分化细胞的改变,同时观察DIC在疾病过程中的发生和转归。结果①维甲酸治疗APL过程中,白细胞升高是一个常见症状,也会发生高细胞综合征,需积极处理;②维甲酸诱导过程中,外周血、骨髓中诱导分化细胞的出现对诊断、疗效评价有着重要作用;③血小板的回升在维甲酸治疗过程中,常提示疾病的缓解;④维甲酸治疗APL,减少了DIC的发生,改善了APL的出血程度,大大提高了APL的缓解率。结论维甲酸治疗APL初期,血液学的改变评估对于本病确诊及疗效评判有着重要作用,为进一步治疗提供了依据。
Objective To probe into hematological early shift and significance of children with acute promylocytic leukemia （APL） treated by all-trans retinoic acid （ATRA）. Methods The general data and information about early leukocyte, platelets and induction of differentiation cells, diagnosis, treatment protocol and prognosis, and DIC occurrence and prognosis were collected and analyzed among 32 children with APL treated by ATRA and As203. Results Increasing leukeocytosis and retinoic acid syndrome often occurred, which needed treatment aggressively. Appearance of Induction of differentiation cells in the peripheral blood and bone marrow played important roles for diagnosis and treatment outcomes evaluation; Platelets reversion decreased the severity of bleeding and improved remission Conclusion Hematological evaluation played important roles for the diagnosis and during the early treatment phase of ATRA for children with APL, which contributed to of APL significantly. prognosis judgment advanced treatment.
出处
《中国小儿血液与肿瘤杂志》
CAS
2009年第1期26-28,共3页
Journal of China Pediatric Blood and Cancer
