摘要
目的观察垂体后叶素联合硝酸甘油治疗肝硬化食管胃底静脉曲张破裂出血(esophageal and gastric variceal bleeding,EGVB)的临床疗效及安全性。方法选择我科经胃镜下诊断的86例EGVB病例随机分为A、B、C组。A组(32例)以垂体后叶素10 u静注后,继以0.2 u/min加硝酸甘油10～30μg/min持续静滴;B组(28例)以善得定100μg静注后,继以25μg/h持续静滴;C组(26例)以垂体后叶素10 u静注后,继以0.2 u/min持续静滴。止血后剂量减半,持续用药2 d,通过胃管观察各组的止血效果。结果A、B组止血时间均短于C组(P<0.05,P<0.01),A、B组间差异无统计学意义(P>0.05);A、B和C组显效率分别为21.88%、28.57%和11.54%,总有效率分别为75.00%、82.14%和53.85%,B组总有效率高于C组(P<0.05),3组间显效率及A、B组间总有效率差异均无统计学意义(P>0.05)。C组不良反应较多,A、B组间不良反应差异无统计学意义(P>0.05)。结论垂体后叶素联合硝酸甘油治疗肝硬化EGVB有良好的疗效,不良反应较少。
Objective To study the therapeutic effect and safety of pituitrin combined with nitroglycerin in treatment of esophageal and gastric variceal bleeding（EGVB）. Methods 86 patients with EGVB diagnosed by endoscopy were randomly divided into A,B,C groups. Group A（n = 32） were given pituitrin 10 u intravanous injection, followed by continuous intravanous infusion at a speed of 0. 2 u/min pituitrin and 10 -30 μg/min nitroglycerin. Group B（ n = 28 ） were given sandostain 100 μg intravanous injection,followed by continuous intravanous infusion at a speed of 25 μg/h. Group C（n = 26） were given pituitrin 10 u intravanous injection,followed by continuous intravanous in fusion at a speed of 0. 2 u/min. As soon as bleeding stopped, the doses dropped to a half and used continuously for two dyas, the effects of every group were obselwed via a gastric tube. Results The bleeding-controled time of group A and B were shorter than that of group C（P 〈 0. 05 ,P 〈 O. 01 ） , there was no significant difference in the bleeding-controled time between group A and B（P 〉 0. 05）. The remarkale effectual rate of group A, B and C were 21.88% ,28.57% and 11.54% respectively. The total effective rate of them were 75.00% ,82. 14% and 53.85% respectively. The total effective rate of group B was higher than that of group C. There was no significant different in the remarkable effectual rate among the three groups and the total effective rate between group A and B （ P 〉 0. 05 ）. The adverse events of group C were more than those of group A or B. There was no difference of the radverse events between group A and B （ P 〉 0.05 ） . Conclusion Pituitrin combined with nitroglycerin has good clinical efficacy and safety in treatment of EGVB.
出处
《临床消化病杂志》
2009年第1期46-48,共3页
Chinese Journal of Clinical Gastroenterology
