摘要
应用高效液相色谱法（HPLC）观察了狗皮巴布膏体外经皮渗透性，采用两室扩散模型对脱毛小鼠皮进行了实验观察。结果表明狗皮膏巴布剂透皮吸收的可行性，其透皮量随着药物浓度的增加和时间的延长而增多，低浓度12．5mg生药／mL在180min时的累积透皮量已不再增加。此结果为狗皮膏巴布剂的临床应用提供了实验基础。
Percutaneous absorption of Goupibabu Plaster was studied using HPLC,adopting simple diffusion cell model to observe its permeation through hairless mouse skin. The result showed that Goupibabu plaster can evidently permeate through the skin,and the amount absorbed increased exponentially with content and time.
出处
《中草药》
CAS
CSCD
北大核心
1998年第1期23-25,共3页
Chinese Traditional and Herbal Drugs
