摘要
目的探讨内镜下氩离子凝固术(argon plasma coagulation,APC)联合抑酸治疗对Barrett食管(Barrett′s esopha-gus,BE)的临床疗效。方法内镜下以APC对36例病理证实为肠上皮化生的BE完全损毁化生黏膜,再给予奥美拉唑抑酸治疗。术后进行内镜、病理随访12个月。结果36例均完成治疗,其中需要1次治疗者25例,2次者10例,3次者1例。34例达到完全的鳞状上皮再生(94.4%),2例再生的鳞状上皮间混有岛状的柱状上皮(5.6%)。12个月后共有5例出现内镜下可见的复发。术后出现36例胸骨后疼痛,2例黏膜下气肿,1例吞咽不畅。结论内镜下APC联合抑酸治疗BE安全、有效,但有一定比例的复发和残留。
Objective To explore the clinical effect of the argon plasma coagulation（APC）combined with omeprazole on Barrett＇s esophagus （BE）. Methods Thirty-six patients with Barrettes esophagus confirmed by endoscope and pathology method were treated with APC and successively acid suppression therapy. All the patients were rechecked by endoscope and pathology method on 3,6 and 12 month after treatment. Results The follow up was accomplished in all patients. The eradication was obtained in 25 cases by only one session and 10 cases two sessions, 1 cases three sessions. The complete squamous reepithelialization was observed in 34 patients （94.4 %）,whereas remnant islands of columnar epithelium mixed with squamous reepithelialization in the original places were observed in 2 patients（5.6%）. The reappearance of columnar epithelium was observed in 5 patients during follow-up. Retro- sternal pain was the most frequent symptom,and 2 cases suffered from submucosal emphysema, 1 case temporary dysphagia. Con- clusion The APC therapy combined with esomeprazole is effective and safe in the reversal of BE However,recurrences and residual of BE are present in minority of patients.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第4期415-416,418,共3页
Chongqing medicine
关键词
BARRETT食管
氩离子凝固术
内镜
奥美拉唑
barrettp＇s esophagus
argon plasma coagulation
endoscopically therapy
omeprazole
