摘要
目的观察血清脂蛋白(a)[Lp(a)]在慢性肺原性心脏病(下称肺心病)的临床意义。方法采用全自动生化分析仪分别检测50例慢性阻塞性肺病(COPD)、35例慢性肺心病及45例健康志愿者血清三酰甘油(TG)、总胆固醇(TCH)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及Lp(a)水平。结果CPPD及肺心病组TG、TCH、HDL、Lp(a)、ApoB升高,LDL、ApoA1、ApoA1/ApoB降低,肺心病组Lp(a)水平较COPD组升高更为明显,各组间比较提示Lp(a)差异有统计学意义。结论脂蛋白(a)的异常更能反映慢性肺原性心脏病的脂质代谢异常,Lp(a)高低与慢性肺原性心脏病发病有相关性。
Objective To investigate the clinical significance of lipoprotein （a） [Lp （a）] in patients with chronic pulmonary heart disease. Methods The fully automatic biochemical analyzer was applied to measuring the serum levels of triglyeeride （TG）, total cholesterol （TCh）, high density lipoprotein （ HDL）, low density lipoprotein （LDL）, apolipoprotein A1 （ApoA1） ,apolipoprotein B （ApoB） and Lp （a） in 50 patients with chronic obstructive pulmonary disease （COPD group）, 35 patients With chronic pulmonary heart disease （pulmonary heart disease group） and 45 healthy volunteers （healthy control group）. Results The serum levels of TG,TCh, HDL,Lp （a） and ApoB were significantly higher,and the levels of LDL, ApoA1 and ApoA1/ApoB were significantly lower in COPD group and pulmonary heart disease group than those in healthy control group, especially in pulmonary heart disease group, the Lp （a） level was more elevated. There was statistical difference of Lp （a） level among the three groups. Conclusion Plasma Lp（a） is a sensitive index for lipid metabolic abnormality in patients with chronic pulmonary heart disease. There is association between the level of Lp （a） and the morbidity of chronic pulmonary heart disease.
出处
《检验医学与临床》
CAS
2009年第4期256-256,258,共2页
Laboratory Medicine and Clinic
关键词
肺心痛
血脂
脂蛋白(a)
pulmonary heart disease
blood lipids
lipoprotein （a）
