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益气活血法治疗心绞痛(气虚血瘀证)随机对照试验的系统评价 被引量:3

Systematic review on randomized controlled trials for qi-supplementing and bloodquickening treatment of angina pectoris due to qideficiency and blood stasis
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摘要 目的系统评价益气活血法对心绞痛(气虚血瘀证)的疗效及安全性。方法两名作者独立收集资料和评价纳入文献质量,运用meta分析对资料进行定量综合,评价不良反应。结果①对30项研究的临床疗效有效率合并效应量的检验:OR合并=3·6,其95%CI为[2·84,4·56];②对25项研究的心电图疗效有效率合并效应量的检验:OR合并=2·49,95%CI为[2·05,3·02];③有3篇论文报道患者出现胃肠不适、头痛等不良反应,益气活血组1例,发生率为2·08%;对照组8例,发生率为5·56%;④有12篇论文报道患者治疗前后的血、尿、粪常规、肝肾功能均未发现异常变化。结论现有证据提示益气活血法能提高冠心病(气虚血瘀证)的治疗疗效,且不良反应少,为中医辨证论治理论提供了科学的依据。 AIM To evaluate the curative effect and safety of qi-supplementing and blood-quickening on angina pectoris due to qi-deficiency and blood stasis. METHODS Two authors collected data and evaluated the quality of the included data independently. The data were quantified by meta-analysis to review the adverse drug reactions. RESULTS (1)Test of the combined curative effect of 30 studies showed an OR affiliate of 3.6, 95% and the confidence interval of OR was [2. 84, 4.56], P 〈0. 01. The result of meta-analysis was statistically significant; (2)Test of the combined curative effect based on the cardiograms in 25 articles showed an OR affilia'.e of 2.49, 95% and the confidence interval of OR was [2.05, 3.02], P 〈0.01; (3)In 3 articles, some patients were reported to have adverse reaetions such as gastrointestinal tract disorder and headache, in which 1 patient was included in the qi-supplementing and blood-quickening group (2.08%), while 8 patients were included in the control group (5.56%) ; (4)By examining the results of blood, urine and excrement tests as well as liver and renal functions before and after the trial, 12 articles reported no significant changes. CONCLUSION The evidence obtained indicates that qi-supplementing and blood-quickening can improve curative effect and decrease adverse reactions.
出处 《心脏杂志》 CAS 2009年第1期54-59,共6页 Chinese Heart Journal
基金 军队中医药研发推广专项课题资助(重大临床攻关 2006191001)
关键词 益气活血 冠状动脉疾病 心绞痛 气虚血瘀证 meta分析 qi-supplementing and blood-quickening coronary disease angina pectoris qi-deficiency and blood stasis syndrome meta analysis
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