摘要
目的观察大剂量阿司匹林并氟伐他汀钠治疗短暂性脑缺血发作(TIA)安全性、效果以及对血小板计数、凝血功能、血脂的影响。方法将96例TIA病人随机分为2组,对照组口服阿司匹林肠溶片300 mg,每日1次,连用10 d,后改为阿司匹林肠溶片100 mg,每日1次,长期服用。治疗组在对照组用药的基础上同时给予氟伐他汀钠40 mg,每日1次,晚餐时口服。所有病人均辅以血塞通400 mg加生理盐水250 mL静脉滴注,并根据病情给予抗高血压、降血糖、抗心力衰竭等基础治疗。两组治疗前及治疗后第30天分别行血小板、凝血功能及血脂测定。结果两组病人疗效比较差异有显著性(Hc=6.73,P<0.01);两组病人治疗前后凝血功能测定值均在正常范围内,差异无显著性(P>0.05);两组病人治疗后TC、LDL-C、TG及HDL比较差异均有显著性(t=2.95～8.21,P<0.01)。结论大剂量阿司匹林并氟伐他汀钠治疗TIA安全、有效。
Objective To observe the safety and effect of large-dose Aspirin plus fluvastatin sodium for transient ischemic attack （TIA） and its impact on blood platelet, blood clotting and blood lipid. Methods Ninety-six TIA patients were evenly randomized to treatment group and control group. The patients in control group were given Aspirin 300 mg, once a day, for 10 days, then 100 mg, once a day, for long-term administrations those in treatment group were given fluvastatin sodium 40 mg, once daily, at supper, in addition to Aspirin same as control group. All the patients were also offered intravenous XUE SAI TONG 400 mg with normal saline 250 mL. Antihyperglycemic, antihypertensive or anti-heart-failure measures were given when needed. The platelet, blood clotting, and blood lipid were detected before and 40 days after treatment. Results The difference of outcome between the two groups was significant （Hc = 6.73,P〈0.01）. The mean value of coagulation function test done in both groups before and after therapy was within normal limit without significant difference between them （P〉0.05）. After treatment, the difference of total cholesterol, triglyceride, low density lipoprotein, and high density lipoprotein between the two groups was significant （t= 2. 95-8.21 ,P〈0.01）. Conclusion High-dose Aspirin plus fluvastatin sodium is safe and effective in the treatment of TIA.
出处
《齐鲁医学杂志》
2009年第1期61-62,64,共3页
Medical Journal of Qilu
