摘要
目的为了解内皮素（ＥＴ）及降钙素基因相关肽（ＣＧＲＰ）与糖尿患者不同阶段时肾血流的关系。方法肾彩色多普勒超声检查确定为糖尿病肾血流正常组（Ａ组）１５例、糖尿病肾血流减少组（Ｂ组）１５例，正常对照组１８例。分别采血测定血浆ＥＴ－１和ＣＧＲＰ浓度。结果Ａ组ＥＴ－１水平低于正常对照组（Ｐ＜０．０１），Ｂ组ＥＴ－１水平高于正常对照组（Ｐ＜０．０１）。二组ＥＴ－１水平与肾动脉收缩期峰值血流速度（Ｖｍａｘ）、肾动脉血流量（Ｑ）呈负相关（Ｐ＜０．０１），与尿白蛋白排泄率（ＵＡＥＲ）呈正相关（Ｐ＜０．０５）。二组的ＣＧＲＰ水平均低于正常组（Ｐ均＜０．０１），但Ａ与Ｂ组的ＣＧＲＰ水平差异无显著性（Ｐ＞０．０５）。未发现ＣＧＲＰ水平与Ｖｍａｘ、Ｑ和ＵＡＥＲ呈相关关系。结论ＥＴ－１在糖尿病不同阶段时对肾血流量的病理生理作用可能不同；糖尿病患者呈现低ＣＧＲＰ血症，但它对不同阶段的糖尿病肾血流的影响尚有待探讨。
bjective To elucidate the relationship between endothelin (ET) and calcitonin gene related peptide (CGRP) in diabetics in different stages. Methods Determined by renal colour doppler ultrusound examination, 15 cases of diabetics with normal renal blood flow (group A)、 15 cases of diabetics with decreased renal blood flow (group B), and 18 controls were studied. ET1 and CRGP in plasma of all subjects were measured. Results The level of ET1 in group A was lower than controls (P<001) whereas the concentration of ET1 in group B was greater than controls (P<001). The ET1 in both groups was negatively related with renal systolic artery blood maximal velocity (Vmax) and the quantity of renal artery blood (Q) (P<001). It was positively related with urine albumin eliminate rate (UAER) (P<005). The level of CGRP in both of group A and B was lower than controls (P<001). However, the difference of CGRP between group A and B was not significant (P>005). The level of CGRP was not also related with Vmax、Q and UAER. Conclusion ET1 may play different pathophysiological roles in the regulation of renal blood flow in different stages of diabetics. Diabetics have lower level of CGRP. However, its influence towards the renal blood flow in different stages of diabetics should be further studied.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1998年第1期37-39,共3页
Chinese Journal of Nephrology
关键词
糖尿病
肾血流
内皮素
CGRP
Diabetes Renal blood flow Endothelin Calcitonin gene related peptide
