摘要
目的:探讨安定联合氟马西尼应用于无痛胃镜的临床效果.方法:我院接受无痛胃镜检查的患者86例,随机分成两组.Ⅰ组(42例)静脉注射给予丙泊酚2mg/kg麻醉;Ⅱ组(44例)给予安定0.2-0.6mg/kg静脉注射,检查完毕立即给予氟马西尼催醒.麻醉过程中观察麻醉后心率、麻醉起效时间、术后清醒时间、麻醉深体动、呼吸暂停、术中呛咳例数等指标.结果:给药后心率、术后清醒时间Ⅰ组与Ⅱ组间无统计学差异.麻醉深度体动率(14.3% vs 34.3%,P<0.05)、起效时间(45±11s vs 58±13s,P<0.05)、呛咳发生率(11.9% vs 29.5%,P<0.05)、呼吸暂停率(54.8% vs 31.8%,P<0.05)Ⅰ组优于Ⅱ组.结论:安定联合氟马西尼应用于无痛胃镜检查,虽然有部分缺陷,但因其给药方便,不须麻醉医师在场,且安全性高、成本低等优点,仍可临床推广.
AIM： To evaluate clinical efficacy of diazepam in combination with flumazenil in painless gastroscopy.
METHODS： Eighty six patients undergoing painless gastroscopy at our hospital were randomly divided into two groups. 2 mg/kg, iv. of propofol was administrated in group Ⅰ （n = 42 cases）, while diazepam 0.2-0.6 mg/kg flumazenil 0.5-1.0 mg was first administrated and then flumazenil was given in group Ⅱ （n = 44 cases）. Indicators such as heart rate, onset time of anesthesia, fixedrate depth of anesthesia, the incidence of choking, apnea rate were detected during anesthesia.
RESULTS： No significant differences were found between group Ⅰ and group Ⅰ in heart rate during operation and regaining conscious- ness time. Group Ⅰ was superior to group Ⅰ in fixed-rate depth of anesthesia （14.3% vs 34.3%, P 〈 0.05）, onset time （45 ± 11 s vs 58 ± 13 s, P 〈 0.05） and the incidence of choking （11.9% vs 29.5%, P〈 0.05） during operation, but the apnea rate was higher （54.8% vs 31.8%, P 〈 0.05）.
CONCLUSION： Diazepam in combination with flumazenil is of high safety and low cost, and the operation can be carried without an anesthetist, thus it still enjoys a good application in painless gastroscopy though with some faults.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第3期326-328,共3页
World Chinese Journal of Digestology
关键词
安定
氟马西尼
胃镜
麻醉
Diazepam
Flumazenil
Gastroscopy
Anesthesia
