摘要
目的：研究胃癌及胃炎组织中多药耐药基因产物P糖蛋白（P－gP）的表达。方法：采用免疫组化方法检测P－gP的分布。结果：各组胃癌及胃炎组织中均有P－gP表达，其中慢性胃炎与管状及乳头状癌、与低分化及未分化癌比较，P＜0．01，差异有显著性意义。印戒细胞癌与低分化及未分化癌比较，P＜0．01，差异有显著性意义。结论：癌组织P－gp表达较慢性胃炎强，但癌组织中P－gP表达不均衡。
Aim: To study mdr1 gene product (P-gp) expression in the gastric carcinoma and chronic gastritis.Methods: 43 cases of gastric carcinomas and 7 cases of chronic gastritis were studied by immunohistochemistry to determin P-gp. Results: P-gp was detected in each group of the gastric carcinoma and in the chronic gastritis. The expression of P-pg in the group of chronic gastritis, tubular & papillary adenocarcinoma, poorly differentiated & undifferentiated carcinoma had distinct difference (P<0. 01). The expression of P-gp in the group of poor1y differentiated & undifferentiated carcino a and the group of signet-ring cell carcinoma also had distinct difference (P<0. 01 ). Conclusion: There was higher level of P-gp in the gastric carcinoma than in the chronic gastrtis. But, the expressions of P-gp in the gastric carcinoma were not balance.
出处
《重庆医学》
CAS
CSCD
1998年第1期13-14,共2页
Chongqing medicine
