摘要
目的探讨子痫前期(PE)患者尿酸(UA)、肌酐(Cr)和尿素氮(BUN)水平的变化及其临床意义。方法采用生化分析仪检测42例PE患者及38例健康妊娠晚期孕妇血清UA、Cr和BUN水平。结果(1)PE患者与健康妊娠孕妇相比,血清UA、Cr和BUN含量显著升高,差异有统计学意义(P<0.05)。(2)轻度PE患者血清UA、Cr及BUN含量呈升高趋势,但与健康妊娠晚期孕妇比较,仅血清UA含量增高;重度PE患者与健康孕妇比较,3项指标均明显增高,差异有统计学意义(P<0.05)。(3)重度PE患者血清UA、Cr和BUN含量显著高于轻度PE患者,差异有统计学意义(P<0.05)。结论血清UA、Cr和BUN水平的升高可提示妊娠高血压患者肾功能受损;血UA可作为判断PE肾功能损害较敏感的指标;血清UA、Cr和BUN对评价和监测妊娠高血压肾功能受损程度具有一定应用价值。
Objective To investigate the changes of serum biochemical parameters for renal function [uric acid （UA）, creatinine （Cr） and urea nitrogen （BUN）] and their clinical significance in patients with preeclampsia. Methotis Biochemical analysis was used to examine the levels of serum UA, BUN and Cr in 42 patients with preeclampsia （preeclampsia group） and 38 healthy pregnant women during late trimester （normal pregnancy group）, and the results were compared and analyzed. Results The levels of serum UA, Cr and BUN in preeclampsia group were significantly higher than those in normal pregnancy group （P〈0.05）. The levels of serum UA, Cr and BUN in slight preeclampsia group tended to increase, but the significant difference was found only in elevated serum level of uric acid between slight preeclampsia group and normal pregnancy group （P〈0.05）. All three indicators were markedly elevated in severe preeclampsia group as compared with those of normal pregnancy group （P〈0.05）. The levels of three indicators were significantly higher in severe preeclampsia group than those of slight preeclampsia group （P〈 0.05）. Conclusion High levels of serum UA, BUN and Cr are indicators of renal function impairment in patients with gestational hypertension; serum uric acid can be used as a sensitive marker for renal function impairment following gestational hypertension.
出处
《检验医学与临床》
CAS
2009年第5期321-322,共2页
Laboratory Medicine and Clinic
关键词
子痫
高血压
妊娠并发症
心血管
肾功能
妊娠末期
eclampsia
hypertension
pregnancy complications,cardiovascular
kidney function
pregnancy trimester, third
