摘要
目的探讨超重和肥胖对原发性IgA肾病患者临床及病理指标的影响。方法回顾性分析690例IgA肾病患者的临床及病理资料,根据体质指数(BMI,kg/m2)分为四组,分别比较低体重(BMI<18.5,n=32)、正常体重(BMI18.5～23.9,n=259)、超重(BMI24～27.9,n=252)和肥胖(BMI≥28,n=147)四组间的临床和病理指标,并按年龄段进行分层分析。结果超重和肥胖IgA肾病患者以男性为主(P<0.05),超重和肥胖组年龄、平均动脉压、甘油三酯、血尿酸显著高于正常体重组(P<0.01)。超重和肥胖组肾脏病理总积分显著增加,肾小管间质积分及肾内血管积分显著高于低体重及正常体重组(P<0.05)。超重和肥胖对IgA肾病临床和病理指标的不利影响,以20～40岁年龄段最为明显。结论超重和肥胖与许多影响IgA肾病进展的危险因素有关,尤其是青壮年,应重视并早期干预。
Objective To explore the effect of different BMI levels on clinical and pathological characteristics in patients with immunoglobulin A nephropathy （IgAN）. Methods Clinical and pathological data of 690 subjects with biopsyidentified IgAN were collected and analyzed in different groups of body mass index[BMI（kg/m^2）]. All cases were divided into low weight group（〈18.5, n = 32）, normal weight group（18.5 - 23.9, n = 259）, overweight group（24-27.9,n=252）,obesity group（≥28,n=147） . Results In overweight and obesity groups,the majority was male（P〈0.05） and mean arterial pressure, serum triglyceride, serum uric acid were significantly higher than low weight group and normal weight group（P〈0. 01）. In both overweight and obesity groups, BMI at the time of renal biopsy was significantly associated with the severity of pathological renal lesions,especially tubulointerstitial and vascular lesions. The adverse effects of overweight and obesity on the clinical and pathological features of IgAN were severe at the age of 20-40 years old. Conclusions Overweight and obesity may be an important risk factor affecting the progression of IgAN.
出处
《北京医学》
CAS
2009年第3期141-145,共5页
Beijing Medical Journal
基金
国家自然科学基金重点项目(30630033)
国家重点基础研究发展973计划项目(2006CB503900)
