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高效液相色谱法测定牙鲆中两种探针药物及其药动学研究 被引量:1

Determination on 2 Kinds of Probe Drugs in Flounder by High-performance Liquid Chromatography(HPLC) and Study on Their Pharmacokinetics
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摘要 以健康牙鲆为试验动物,对其注射氨苯砜和氯唑沙宗2种探针药物,采用RP-HPLC法测定其血浆中氨苯砜和氯唑沙宗的浓度。结果表明,RP-HPLC测定方法专属性强、操作简便,能在11 min内将2种探针药物有效分离。 With the healthy flounder as the tested animals, they injected with 2 kinds of probe drugs such as dapsone and chlorzoxazone. The concn, of dapsone and chlorzoxazone in plasma of flounder were determined by RP-HPLC method. The results showed that the RP-HPLC method had strong specificity with simple operation, by which the 2 probe drugs could be effectively separated in 11 min.
出处 《安徽农业科学》 CAS 北大核心 2009年第5期1886-1888,共3页 Journal of Anhui Agricultural Sciences
基金 国家自然科学基金(30700617) 公益性行业专项基金(ny-hyzx07-046)
关键词 高效液相色谱法 牙鲆氯唑沙宗 High-performance liquid chromatography Flotmder
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