摘要
目的:观察埃索美拉唑(esomeprazole)、克拉霉素、甲硝唑三联治疗法治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性十二指肠溃疡的疗效。方法:将124例确诊为Hp阳性的十二指肠溃疡患者随机分为观察组和对照组,每组各62例。观察组给予埃索美拉唑20mg、阿莫西林1.0g、克拉霉素0.5g,均为2次/d。对照组给予奥美拉唑20mg、阿莫西林1.0g、克拉霉素0.5g,均为2次/d。共7d。2组患者在治疗4w后复查胃镜并检测Hp感染状况,观察腹痛缓解率、溃疡愈合率、Hp根除率及用药后的不良反应等。结果:观察组和对照组的Hp根除率为88.71%、82.26%,溃疡愈合率为91.94%、88.71%,2组比较差异均无统计学意义(P>0.05);观察组d1和d2的腹痛缓解率分别为33.87%和58.06%,明显高于对照组的16.13%和37.10%,差异具有统计学意义(P<0.05)。结论:埃索美拉唑三联疗法治疗Hp阳性十二指肠溃疡的疗效优于奥美拉唑三联疗法,腹痛较快得以缓解,值得临床推广应用。
Objective：To observe the curative effect of triple schemes of esomeprazole, clarithromycin and metronidazole in the treatment of duodenal ulcer with positive helicobacter pylori（ Hp）. Method： A total of 124 cases duodenal ulcer patients, who were diagnosed as positive Hp, were evenly divided into observation group and control group. The esomeprazole of 20 rag, amoxicillin of 1.0 g and clarithromycin of 0.5 g were used in the observation group for two times a day. The omeprazole of 20 mg, amoxicillin of 1.0 g and clarithromycin of 0.5 g were used in the control group for two times a day. The total course of treatment was 7 days. After 4 - week ＇ s treatment, the patients in two groups were reexamined by gastroseope for the pur- pose of checking the Hp infection and rate of relief of abdominal pain, healing rate of ulcer, rate of elimination of Hp and harmful reaction after the use of drug. Result：The rates of elimination of Hp in observation group and control group were respectively 88.71% and 82.26% and healing rates were respectively 91.94% and 88.71%, whose differences were no any statistical significance （P 〉 0.05）. The rates of relief of abdominal pain of observation group in first day and second day were respectively 33.87% and 58.06%, which were obviously higher than those （ 16.13% and 37.10% ） in control group. The differences had the statistical significance （ P 〈 0.05 ）. Conclusion： The triple esomeprazole schemes in the treatment of positive Hp duodenal ulcer is better than triple omeprazole schemes, by which the abdominal pain could be relieved quickly. Therefore, it is valuable for the clinical popularization.
出处
《河北医学》
CAS
2009年第2期186-188,共3页
Hebei Medicine
