摘要
目的研究不同注药速度与注药部位对芬太尼诱发呛咳的发生率与出现时间的影响。方法选择75例ASAI～II级患者,随机分为3组,分别静脉注射芬太尼4μg/kg。A组通过前臂静脉通道以2s的速度注药;B组静脉通道建立在足背或踝前大隐静脉部位,以2s的速度注药;C组通过前臂静脉通道以15s的速度注药。观察各组呛咳发生率与从开始注射到呛咳出现的时间。结果A、B、C组的呛咳发生率分别为44%、52%、8%,呛咳开始出现时间分别为(16.1±2.7)s、(21.9±3.7)s、(23.3±3.2)s。与A组相比,B组呛咳出现的时间明显滞后(P<0.05);C组的呛咳发生率比A组明显下降(P<0.05),呛咳出现的时间比A组明显滞后(P<0.05)。结论在相同的部位注射相同剂量的芬太尼,不同的注射速度既会影响呛咳的发生率也会影响呛咳的发生时间;相同的速度注射相同剂量的芬太尼,呛咳的发生时间在上肢静脉通道快于下肢静脉通道,但呛咳发生率没有显著差异。
Objective To explore the effect of intravenous injection rate and site of fentanyl on the incidence and onset time of fentanyl-induced cough. Methods Seventy-five ASA class Ⅰ or Ⅱ patients were randomized into 3 groups and received intravenous fentanyl administration at 4 μg/kg in different manners. In group A, fentanyl was injected within 2 s into the forearm veins; in group B, fentanyl was injected in 2 s through the dorsal foot veins or the great saphenous vein anterior to the ankle; in group C, fentanyl was injected in 15 s by the same route as in group A. Results The incidence of cough was 44%, 52% and 8%, with cough onset time of 16.1±2.7 s, 21.9±3.7 s and 23.3±3.2 s in groups A, B and C, respectively. Compared with group A, group B hada delayed onset of cough （P〈0.05）, and group C had both a lowered incidence of cough （P〈0.05） and delayed onset of cough （P〈0.05）. Conclusions The rate of fentanyl injection through the same peripheral venous access at the same dose may affect the incidence and onset time of cough. At the same dose and injection rate of fentanyl, forearm venous access of injection resulted in earlier onset of cough than lower limb venous access, but the incidence is similar.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第2期339-340,共2页
Journal of Southern Medical University
关键词
芬太尼
呛咳
给药速度
外周静脉
fentanyl
cough
injection rate
peripheral vein
