摘要
目的观察头孢泊肟酯治疗急性细菌感染的安全性、有效性。方法115例细菌感染性疾病病人随机分为2组:对照组55例,男性24例,女性31例,年龄(43±s 13)岁;试验组60例,男性35例,女性25例,年龄(42±13)岁。对照组予头孢克肟200 mg,po,bid;试验组予头孢泊肟酯100 mg,po, bid,疗程均为7～12 d。观察2组临床疗效、细菌学疗效及不良反应情况。结果试验组和对照组临床痊愈率分别为73%和69%,有效率分别为93%和91%,细菌清除率分别为98%和94%,均无显著差异(P>0.05)。2组均未出现严重不良反应,不良反应率分别为7%和9%,无显著差异(P>0.05)。结论头孢泊肟酯治疗急性细菌感染安全、有效。
AIM To evaluate the safety and efficacy of cefpodoxime proxetil in the treatment of acute bacterial infections. METHODS One hundred and fifteen patients with bacterial infections disease were divided into 2 groups in random. Fifty-five patients in control group （M 24, F 31, age （43± s 13） year） were treated with cefixime 200mg, po, bid and 60 patients of trial group （M 35, F 25, age （42 ±13） year） with cefpodoxime proxetil 100 mg, po, bid; both with a course of 7 - 12 d. The clinical curative effects, anti- bacteriological effects and adverse reactions were observed. RESULTS In trial and control groups, the cure rates were 73% and 69%, the efficacy rates were 92% and 91%, and the bacterial clearance rates of both groups were 98% and 94% ; and with furthermore drug adverse reactions of 7% and 9%, respectively. There were no statistically significant differences between the results of both groups （P 〉 0.05） . CONCLUSION Cefpodoxime proxetil is effective and safe in the treatment of acute bacterial infections.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2009年第2期111-114,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
头孢菌素类
头孢克肟
细菌感染
随机对照试验
头孢泊肟酯
cephalosporins
cefixime
bacterial infections
randomized controlled trials
cefpodoxime proxetil
