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CD4^＋CD25^＋CD127^lo2-细胞体外抑制效应T淋巴细胞增殖的影响 被引量：6

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摘要 1995年，Sakaguchi等率先在小鼠外周血中分离获得发挥免疫抑制功能的CD4^＋CD25^＋T淋巴细胞，被称为调节性T淋巴细胞（Regulatory Tcells，Treg）。Treg细胞不仅具有抑制自体反应性T淋巴细胞的功能，还能阻止效应性T淋巴细胞的过度增殖和活化，甚至能影响B淋巴细胞产生免疫球蛋白。
作者 王剑 袁向亮 李美星 薛剑 张通通 沈立松
机构地区 上海交通大学医学院附属新华医院检验科
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2009年第3期340-343,共4页 Chinese Journal of Laboratory Medicine
基金 基金项目：上海市科委基础重点研究项目资助课题（07JC14045）
关键词 T淋巴细胞增殖 体外抑制效应 CD4^+CD25^+T淋巴细胞 2-细胞 免疫抑制功能 Treg细胞 免疫球蛋白 B淋巴细胞
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献10

  • 1Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains ( CD25 ). Breakdown of a single mechanism of self- tolerance causes various autoimmune diseases. J Immunol, 1995, 155 : 1151-1164.
  • 2Sakaguehi S, Powrie F. Emerging challenges in regulatory T cell function and biology. Science, 2007,317:627-629.
  • 3Baecher-Allan C, Brown JA, Freeman GJ, et al. CD4+CD25^high regulatory cells in human peripheral blood. J Immunol, 2001, 167 : 1245-1253.
  • 4Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med,2007 ,13 :108-116.
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  • 9Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg ceils. J Exp Med, 2006,203 : 1701-1711.
  • 10袁向亮,沈定丰,卢剑,董平,王剑,李美星,沈立松.CD127用于特异性识别调节性T淋巴细胞的方法建立及临床应用评价[J].中华检验医学杂志,2008,31(5):499-503. 被引量：11

二级参考文献9

  • 1Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alpha-chains ( CD25 ). Breakdown of a single mechanism of selftolerance causes various autoimmune diseases. J Immunol, 1995, 155:1151-1164.
  • 2Wolf AM, Wolf D, Steurer M, et al. Increase in regulatory T cells in the peripheral blood of cancer patients. Clin Cancer Res, 2003,9:606-612.
  • 3Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med, 2004,10:942-949.
  • 4Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science, 2003, 299 : 1057-1061.
  • 5Marson A, Kretschmer K, Frampton GM, et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature, 2007,445:931-935.
  • 6Williams LM, Rudensky AY. Maintenance of the Foxp3- dependent developmental program in mature regulatory T cells requires continued expression d Foxp3. Nat Immunol ,2007 ,8 :277-284.
  • 7Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + Treg ceils. J Exp Med, 2006,203:1701-1711.
  • 8Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med,2006,203:16933-1700.
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共引文献10

同被引文献50

  • 1潘丽娜,时国朝.慢性阻塞性肺疾病与自身免疫[J].中国呼吸与危重监护杂志,2011,10(3):296-298. 被引量：9
  • 2李海禹,丁艳萍,易桂文,曾秋棠,杨文凯.Establishment of Nasal Tolerance to Heat Shock Protein-60 Alleviates Atherosclerosis by Inducing TGF-β-dependent Regulatory T Cells[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2012,32(1):24-30. 被引量：7
  • 3李卫鹏,王福庆.CD4^+CD25^+ Treg的免疫调节作用机制以及临床研究进展[J].现代免疫学,2006,26(2):164-167. 被引量：18
  • 4王英禹,张瑞,张志培,周勇安,孙晓雁.恶性胸腔积液患者T淋巴细胞亚群的变化意义[J].第四军医大学学报,2007,28(5):447-449. 被引量：4
  • 5Viguier M, Lemaitre F, Verola O, et al. Foxp3 expressing CD4^+ CD25high regulatory T cells are over represented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells [J].J Immunol, 2004, 173: 1444-1453.
  • 6Sasada T, Kimura M, Yoshida Y, et al. CD4+CD25+reg ulatory T cells in patients with gastrointestinal malignancies Possible involvement of regulatory T cells in disease progression[J]. Cancer, 2003, 98: 1089-1099.
  • 7Kono KH, Takahashi A. CD4^+ CD25 high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers[J].Cancer Immunol Immunother, 2006, 55: 1064-1071.
  • 8Shen LS, Wang J, ShenDF, etal. CD4^+CD25^+CD127^low/- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression [J]. Clin Immunol, 2009,131:109-118.
  • 9Baratelli F, Lin Y, Zhu L, et al. Prostaglandin E2 induces foxp3 gene expression and T regulatory cell function in human CD4^+ Tcells [J]. J Immunol, 2005,175:1483-1490.
  • 10Yaqub S, Henjum K, Mahic M, etal. Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a cox-2 dependent manner[J]. Cancer Immunol Immunother, 2008,57:813-821.

引证文献6

二级引证文献41

中华检验医学杂志
2009年 第3期

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