摘要
目的利用动脉自旋标记法（ASL）探讨难治性与非难治性抑郁症的脑血流特征。方法选择本院年龄、性别配对的门诊12例难治性抑郁症患者、37例非难治性抑郁症患者和42名健康志愿者，采用流动敏感交互反转恢复序列（FAIR）进行灌注成像。影像处理是将标记和未标记影像相减，然后平均得到灌注加权影像。将3组灌注加权影像采用基于像素分析方法（voxel based analysis，VBA）进行分析，统计采用ANOVA方差分析，并将年龄作为参变量。结果非难治性抑郁症患者脑血流灌注变化的区域主要包括两个额叶-皮质通路，即灌注降低区域在左额叶和丘脑（边缘．丘脑．皮质通路），而灌注增加区域在双侧海马、右豆状核及左侧扣带回前部（边缘-纹状体-苍白球-丘脑通路）。相比之下，难治性患者灌注降低区域主要涉及两侧额叶区（边缘-丘脑-皮质通路），而无灌注增加的区域。结论该研究揭示了抑郁症患者脑异常灌注区域，并利用ASL技术发现难治性与非难治性抑郁症患者存在不同的灌注异常区域。
Objective To investigate the brain perfusion changes in patients with refractory depressive disorder （RDD） and non-refractory depressive disorder （NDD） using arterial spin labeling （ASL）. Methods Present study included 12 patients with RDD, 37 patients with NDD and 42 controls, and their age, sex and handedness were matched among the three groups. FAIR sequences were performed using a 3 T MR imaging system with an 8 channel phase array head coil. The labelled and controled images were subtracted and then averaged to obtain perfusion-weighted images. The first 2 images were excluded to avoid T1 equilibrium effects and then voxel based analysis was performed using SPM2. One way ANOVA analysis using age as covariance （ thresholded at P 〈 0. 01 uncorrected ） was performed. Results Patients with NDD showed regional alteration of the brain perfusion, mainly involved in two frontal- subcortical circuits, i.e. significantly decreased perfusion in the left frontal and thalamus （the limbicthalamo-cortical circuit） whereas significantly increased perfusion in bilateral hippocampi, right lentiform and left anterior cingulated gyms （the limbic-striatal-pallidal-thalamic circuit）. In contrast, patients with RDD presented significantly decreased perfusion involving bilateral frontal areas （ the limbic-thalamo-cortical circuit） whereby no significantly increased perfusion areas were observed. Conclusion In addition to the reported experimental evidences, our results suggest that the RDD is associated with inactivity of bilateral frontal areas, while the NDD is associated with inactivity of left frontal areas and overactivity of bilateral limbic system.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2009年第3期244-248,共5页
Chinese Journal of Radiology
基金
国家杰出青年科学基金（30625024）
“十五”国家科技攻关资助项目（2004BA720A21-01）
关键词
磁共振成像
抑郁症
灌流
Magnetic resonance imaging
Depressive disorder
Perfusion
