摘要
目的探讨结缔组织疾病(CTD)患儿肺功能受损情况,为CTD患儿肺部并发症的早期发现及预后评估提供参考。方法2006年10月-2007年7月住院或门诊随访的CTD患儿35例(CTD组),男16例,女19例,无咳嗽、气促等症状,胸片检查正常。应用Master-Screen Paed肺功能仪测定其常规肺功能和脉冲振荡肺功能,并与健康对照组32例(男13例,女19例)比较。应用STATA7.0软件对CTD组和健康对照组的肺功能数据进行统计学分析。结果CTD患儿肺功能异常率为57.14%,17例(48.57%)表现为轻度至中度的限制性通气障碍,9例(占25.71%)伴小呼吸道功能下降,2例(占5.71%)表现为限制性和阻塞性混合通气障碍。反映肺通气功能的参数(最大肺活量、用力肺活量、一秒钟用力呼气容积)CTD组均明显低于健康对照组[(77.66±20.22)%vs(94.39±11.27)%;(79.05±21.45)%vs(94.89±11.46)%;(84.91±23.29)%vs(103.62±12.96)%Pa<0.01]。反映中、小呼吸道功能的参数(呼出50%肺活量时最大呼气流速、呼出75%肺活量时最大呼气流速)CTD组均明显低于健康对照组[(85.82±31.02)%vs(102.82±27.32)%;(74.52±32.59)%vs(98.75±40.59)%Pa<0.05]。反映呼吸道阻力参数(总呼吸道阻力、中心呼吸道阻力、周边弹性阻力、共振频率)在CTD组和健康对照组间比较均无显著差异(Pa>0.05)。结论CTD患儿肺功能改变主要为限制性通气障碍伴不同程度的小呼吸道功能下降,肺功能测定可早期反映CTD患儿病情发展的进程和程度,对CTD患儿肺部损伤的评估和及时治疗有较大帮助,应作为CTD患儿的常规检查项目。
Objective To expore the pulmonary function in children with connective tissue disease（ CTD）, and evaluate lung complication and prognosis of children with CTD. Methods Thirty -five children with CTD （male 16 cases,female 19 cases） who visited children＇s hospital of Fudan university during Oct. 2006 to Jul. 2007 and had non - respiratory symptoms were selected. The pulmonary function of them were measured by Master- Screen Paed and the data were compared with 32 children as the healthy control group （male 13 cases,female 19 eases ）. The data were analyzed by STATA 7.0 software. Results The abnormality ratio of lung functions were 57.14%, 17 cases （48.57%） children with CTD displayed restrictive ventilatory disorder,9 cases （25.71% ）children with CTD displayed dropped function, of small airway, 2 cases（5.71% ）children displayed dominant restrictive ventilatory disorder and coexisted with obstructive ventilatory disorder. The parameters of pulmonary ventilation such as maximal vital capacity, forced vital capacity, forced expiratory volume in 1 second,in CTD group were significandy lower than those in healthy control group [ （77.66 ± 20. 22 ） % vs （94. 39 ± 11.27 ） % ; （79.05 ± 21.45 ） % vs （94. 89 ± 11.46 ） % ; （ 84. 91 ± 23.29）% vs（103.62±12.96）% P〈 0.01].The parameters of small airway function such as forced expiratiratory flow after exhaling50% of vital capacity, forced expiratory flow after exhaling 75% of vital capacity in CTD group were significantly lower than those in healthy control group [（85.82±31.02）%vs（102.82±27.32）%;（74.52±32.59）% vs（98.75±40.59）% Pa 〈 0. 05 ] . There were no significant differences about the parameters of airway resistance （total airway resistance, center airway resistance, peripheral elastic resistance, resonance frequency） between 2 groups（Pa 〉 0.05 ）. Conclusions The most characteristic pulmonary function changes in children with connective tissue disease are restrictive ventilatory disorder with some disorder in small airway function. Pulmonary function test shall become routine test in children with connective tissue disease.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第4期280-281,310,共3页
Journal of Applied Clinical Pediatrics
关键词
结缔组织疾病
肺功能
限制性通气障碍
connective tissue disease
pulmonary function
restrictive ventilatory disorder
