摘要
目的了解不同避孕措施长期使用者生殖道人乳头状瘤病毒(HPV)感染的情况。方法采用聚合酶链反应(PCR)检测服用口服避孕药或使用宫内节育器5年以上的妇女226人宫颈分泌物中HPV DNA,研究对象按避孕措施分成1号片组、复方18-甲组和宫内节育器组。结果三组研究对象的HPV总检出率为14.2%,HPV的检出率复方18-甲组最高,宫内节育器组最低,分别为复方18-甲组20.45%、1号片组11.11%、宫内节育器组8.77%,三组间的差异无统计学意义(P>0.05)。三组中HPV感染者的宫颈均有异常表现,但差异无统计学意义(P>0.05)。结论对有性生活,特别是长期使用避孕措施的妇女提供常规的宫颈涂片检查和HPV检测服务,有助于提高避孕措施使用者的身心健康。
Objective To understand the situation of the human papillomavirus （HPV） infection in women of long-term using combined oral contraceptives （OC） and intrauterine device （IUD）. Methods We performed polymerase chain reaction （PCR） assays on 226 women who have long-term taken Combined Norethisterone, Combined Norgestrel and worn the IUD for birth control. All subjects were divided into three groups： Norethisterone, Norgestrel and IUD according to the use of contraception methods. Results The total detectable rate of HPV was 14.2% . Among the three groups, the detectable rate of HPV in Norgestrel was the highest, and the lowest rate was in the IUD group. The rates were 20.45% in the Norgestrel, 11.11% in the Norethisterone and 8.77% in the IUD, respectively. The rates in the two OC groups were higher than that in the IUD group, but had no significant difference（ P 〉 0.05）. There was no significant difference in clinical symptom among the three groups （ P 〉 0.05 ）, but the two OC groups had much more clinical symptom caused by HPV than that in the IUD group. However, most of women with HPV positive had not clinical symptoms. Conclusions Some of regular cervical smears and HPV testing services should be provided, especially for the long-term users of contraception methods to improve their physical and mental health.
出处
《毒理学杂志》
CAS
CSCD
北大核心
2009年第1期22-24,共3页
Journal of Toxicology
基金
江苏省科技厅公益专项(BM2006709)
关键词
口服避孕药
宫内节育器
人乳头状瘤病毒
聚合酶链反应
Combined oral contraceptives
Intrauterine devices
Human papillomavirus
Polymerase chain reaction
