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卵巢早衰相关基因突变的最新研究进展 被引量：14

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摘要 目前,对卵巢早衰(premature ovarian failure,POF)的病因和发病机制的认识还很不清楚。但无论是基因单核苷酸多态性的分析、家系的研究还是进一步功能性的研究,都显示X染色体上的BMP15、FMR1、FMR2和常染色体上的GDF-9、FSHR、INH、FOXL2、FOXO3a等可能与卵巢早衰的发生有关。但对于各基因进一步的功能研究相对较少,在不同人群中对各基因的研究结果尚缺乏一致性,研究中采纳的POF患者病例数还相对偏少。故需进一步对POF进行分子机制进行研究。
作者 张文静 杜晶 张慧琴
机构地区 复旦大学 上海市计划生育科学研究所
出处 《生殖与避孕》 CAS CSCD 北大核心 2009年第2期96-99,共4页 Reproduction and Contraception
关键词 卵巢早衰(POF) 基因突变 病因学
分类号 R711.75 [医药卫生—妇产科学]
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参考文献34

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  • 2Aaltonen J, Laitinen MP, Vuojolainen K, etal. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF- 9B are expressed in oocytes during early folliculogenesis. J Clin Endocrinol Metab, 1999, 84(8):2 744-50.
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二级参考文献28

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  • 7Takakura K,Takebayashi K,Wang HQ,et al.Follicle-stimulating hormone receptor gene mutations are rare in Japanese women with premature ovarian failure and polycystic ovary syndrome.Fertil Steril,2001,75:207-209.
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生殖与避孕
2009年 第2期

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