摘要
目的探讨Alzheimer病(AD)患者扣带回后部磁共振扩散张量成像(DTI)的特点及其与认知功能改变的相关性。方法对16例AD患者和12名健康老人(正常对照组)行DTI、T1Flair及T2Flari检查,测量扣带回后部各向异性分数值(FA)、平均弥散度(MD)及其λ1、λ2及λ33个特征值,分析上述诸项数值与简易精神状态检查量表(MMSE)评分之间的相关性。结果与正常对照组相比,AD组患者扣带回后部的FA值显著降低(P<0.05),而MD、λ1、λ2及λ3值明显升高(均P<0.05);FA值与MMSE评分不相关(r=-0.054,P>0.05),而MD值与MMSE评分呈显著负相关(r=-0.664,P<0.01);λ1、λ2及λ3值均与MMSE评分呈负相关(r=-0.643,r=-0.69,r=-0.654,均P<0.01)。结论AD患者表现为扣带回后部各向异性损害,且损害程度与临床认知功能评分呈负相关;这种损害反映了AD病理机制中皮质-皮质及皮质-皮质下联系的丢失;DTI可以用来监测AD疾病的进展及评价药物的临床疗效。
Objective To investigate the features of diffusion tensor imaging （DTI） of posterior cingulate gyrus damage and.its correlation with the change of cognition function in patients with Alzheimer＇s disease （AD）. Methods DTI, as well as T1 Flair and T2 Flari were performed in 16 probable AD patients and 12 healthy volunteers to measure the fractional anisotropy （FA）, mean diffusivity （MD） and characteristis values of λ1, λ2 and λ3 in the posterior cingulate gyrus. Correlation analysis was applied to reveal the relationship between values of the FA, MD, λ1, λ2 and λ3 with the MMSE scores. Results In contrast to controls, AD patients had significantly lower FA and significantly higher MD, λ1,λ2 and λ3 in the posterior cingulate gyrus （ all P 〈 0.05 ）. Besides, FA was not correlated with MMSE score （ r = - 0.054, P 〉 0. 05 ）. MD, λ1, λ2 and λ3 of AD patients were strongly negatively correlated with MMSE score（r = - 0. 664, - 0. 643, r =-0.69, r =-0.654 ; all P〈0.01）. Conclusions The posterior cingulated gyrus of AD patients are impaired, and the extent of damage is strongly nagetive correlate with the cognition function. This impairment may reflect the cortico-cortical and cortico-subcortical disconnections in the athomechanism of AD. DTI can use to monitor the AD progression and evaluatie the drug efficacy in vivo.
出处
《临床神经病学杂志》
CAS
北大核心
2009年第1期1-3,共3页
Journal of Clinical Neurology
基金
国家自然科学基金(30400512)
广东省自然科学基金(7300973
7001284
20013137)
广东省社会发展项目(2005B10401047)
广州市科技计划项目(2004Z3-E0151)
