摘要
目的：确定罗哌卡因（ropivacaine，Rop）蛛网膜下隙分娩镇痛的剂量～效应关系。方法：100名拟实施分娩镇痛初产妇，按蛛网膜下隙Rop剂量不同，随机分为Rop 1．0mg（R。）组、1．5mg（R2）组、2．2mg（Rj）组及3．3mg（R4）组，每组25名。有效镇痛的标准为蛛网膜下隙注射Rop 10min内产妇宫缩时VAS评分0～2cm。运用概率单位回归分析（Probit法），建立有效镇痛产妇比例的概率单位（Z值）与蛛网膜下隙Rop对数剂量的回归关系方程，并计算Rop的E％及E％。结果：有效镇痛产妇比例的概率单位（Z值）与Rop对数剂量的回归关系方程为：Probit（Z）=-1．00478±5．67816（10g剂量）；Rop蛛网膜下隙分娩镇痛的ED50为1．50mg（95％可信区间：1．31～1．70mg），ED。为2．93mg（95％可信区间：2．42～4．16mg）。结论：Rop蛛网膜下隙分娩镇痛的ED50为1．50mg，ED95为2．93mg。
AIM： To determine the dose-effect relationship of intrathecal ropivacaine for labor analgesia. METHODS： One hundred premolars in active labor were included in this randomized trial. Ropivacaine was intrathecally administered in a dose of 1.0, 1.5, 2.2 or 3.3 mg. Premolars were considered responders to spinal analgesia if the visual analog scale score for pain was less than 3 cm within 10 min. Group-specific dose-response curves were constructed using a probit regression model. RESULTS： The ED50 and ED95 of ropivacaine were 1.50 mg （ 95 % confidence interval：1.31 - 1.70 mg） and 2.93 mg（95% confidence interval：2.42- 4.16 mg）, respectively. The relationship between the probit of effective analgesic ratio of premolars and the log of dosage of intrathecal ropivacaine was established. Regression equation was Probit（Z） = - 1.00478 ＋ 5.67816（log of dosage）. CONCLUSION： The ED50 and ED95 of ropivacaine are 1.50 mg and 2.93 mg, respectively.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第1期90-93,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
宁波市医学科技项目(2006009)
宁波市优秀中青年卫生技术人才项目(2007201)
关键词
罗哌卡因
蛛网膜下隙
分娩镇痛
剂量
效应
ropivacaine
subarachnoid space
labor analgesia
dosage
effect
