摘要
本文目的为研究早产儿GER发病情况、临床表现及普瑞博思的治疗效果。本组用食管pH动态监测仪测定15例早产儿，临床表现有呕吐、喂养困难、体重增长不良及呼吸暂停。24小时食管pH＜4的百分比大于同龄正常值者为GER阳性。给以口服普瑞博思，10天后复查食管PH监测。研究结果15例中，11例GER阳性发生率为73．3％。所有的临床表现均于治疗后2～3天消失和改善；食管24小时PH＜4时间百分比，治疗前后差异显著，有统计学意义。24小时食管pH监测是检测早产儿GER的良好的方法；普瑞博思能有效控制早产儿GER，且无副作用，均可在临床推广应用。
The aims are to investigate the incidence and clinical manifestations of gastroesophageal reflux (GER) in premature infants and the therapeutic effects of prepulsid on GER.The esophageal pH were monitored in 15 premature infants. The clinical manifestation included vomitiny, difficulty to feed, retardation of weight, and apnea. The patients whose percent of time of esophageal pH<4 in 24 hours were higher than the normal vaue in same age would be considered GER positive and be treated with prepulsid and be reexamined 10 days later.The results Eleven of 15 premature infant showed GER positive, The symptoms disappeared after tredted for 2-3 days. The percent of time of esophageal pH<4 in 24 hours were significant difference before and after treated.We think the incidence of GER in premature infants is relatively high GER relates to the clinical manifestation, such as vomiting, apnea and etc. The monitoring of esophageal pH for 24 hours was better mean for determing GER in premature infants. The effect of prepulsid on GER in premature infants was remarkable and on side effects were seen
出处
《新生儿科杂志》
1998年第2期52-53,共2页
The Journal of Neonatology
