摘要
目的:探讨超分割放射治疗配合小剂量顺铂对食管癌的治疗价值。方法:100例食管癌患者随机分为2组:顺放组(50例),行超分割放疗配合小剂量顺铂化疗;单放组(50例),行单纯超分割放疗。两组患者均随访5年,观察记录两组患者1、3、5年的生存率、死亡率和毒性反应的发生情况。结果:顺放组1年、3年、5年的生存率均明显高于单放组(P<0.05);两组患者的死因均以局部未控或复发为主,但顺放组局部未控和远处转移的死亡率均明显低于单放组(P<0.05);两组均无严重毒副作用发生。结论:超分割放疗配合小剂量顺铂化疗治疗食管癌疗效较好,值得临床进一步研究推广。
Objective:To investigate the therapeutic value of hyperfractionation combined low dose Cisplatin for treatment of esophageal cancer.Methods:100 esophageal cancer patients were randomly divided into 2 groups:H+C group(50 cases),the patients were exerted hyperfractionation combined low dose Cisplatin;C group(50 cases),the patients were simply exerted hyperfractionation.All the patients were followed up for 5 years.The survival rate of patient 1-year,3-year and 5-year after treatment were recorded;the death rate and occurrence of toxic and side-effects were also observed.Results:The survival rate of 1-year,3-year and 5-year of patients in H+C group were obviously higher than C group(P<0.05).The main death causes of 2 groups were recurrence;the death rate of H+C group were obviously lower than C group(P<0.05).No serious toxic and side-effects occurred in 2 groups.Conelusions:Hyperfractionation combined low dose Cisplatin for treatment of esophageal cancer can obtain better therapeutic effects,So it is worth of further studying in clinic.
出处
《承德医学院学报》
2009年第1期16-18,共3页
Journal of Chengde Medical University
关键词
食管肿瘤
超分割放疗
顺铂
Esophageal cancer
Hyperfractionation
Cisplatin
