摘要
对费氏链霉菌HTP6产新霉素的分批发酵动力学进行了研究,并建立了动力学模型。对数生长期最大比生长速率μm为0.0866h-1,产物合成期最大合成速率qp为1.1867×10-4g/(mL·h)。对实验数据与模型模拟值进行拟合检验,表现出很好的适用性,实验平均相对偏差小于5%。表明该动力学模型对费氏链霉菌产新霉素的发酵生产具有实际意义。
The kinetics of neomycin productions by batch fermentation with Streptomyces fradiae HTP6 were studied. The mathematical kinetic models describing the course of Streptomycesfradiae HTP6 fermen- tation were established. The maximal specific growth rate/tin was 0.0866 h^-1 in exponential phase. The maximal specific production rate qp could reach 1.1867×10^-4 g/（mL.h） in antibiotic production phase. The calculated results of models were compared satisfactorily with experimental data, the average relative devia- tion was no more than 5%. This kinetic model had practically guiding producing neomycin in fermentation of Streptomyces fradiae.
出处
《微生物学通报》
CAS
CSCD
北大核心
2009年第3期311-315,共5页
Microbiology China
基金
国家863计划项目(No.2006AA10A209)
国家自然科学基金(No.30800034)
关键词
费氏链霉菌
新霉素
发酵
动力学模型
Streptomycesfradiae, Neomycin, Fermentation, Kinetics model
