摘要
中药小儿七珍丸含有雄黄和朱砂等成分,用于治疗小儿急性惊风和便秘等症。本文报道2例成人长期大量服用小儿七珍丸致慢性砷中毒。例1,女,36岁。因便秘服用小儿七珍丸40～80粒,1次/d,共3年。在开始服药2～3个月后,患者出现乏力、纳差、腹部皮肤黑变。近1年来出现头晕、头痛、失眠、肢端麻木。入院后,查体示:面部、躯干及四肢色素沉着、手掌及足底皮肤增厚,血砷为7.3μg/L,尿砷为0.117mg/L。诊为慢性砷中毒。患者经用二巯丙磺钠治疗3个疗程后症状明显减轻。例2,男,40岁。因便秘服用小儿七珍丸20～80粒,每天1～2次,共7年。用药后患者逐渐出现乏力、纳差、恶心、腹胀、全身皮肤色素沉着、皮肤过度角化、手足麻木、肝脾肿大、贫血,尿砷为4.28mg/L。诊为慢性砷中毒。患者经用二巯丙磺钠治疗5个疗程后,症状明显减轻出院。
The traditional Chinese medicine Xiaoerqizhen pills, which contain realgar and cinnabar, are used for treatment of acute infantile convulsion and constipation. This paper reports that two adults developed chronic arsenic poisoning after prolonged use of highdose Xiaoerqizhen pills. Patient 1, a 36-year-old woman, received 40 - 80 Xiaoerqizhen pills once daily for three years for constipation. Two to three months after starting Xiaoerqizhen pills use, she developed fatigue, anorexia, and dark skin pigmentation on her abdomen. In recent one year, she developed dizziness, headache, insomnia, and numbness of her limb ends. After admission, an examination showed pigmentation on his face, trunk, and extremities, pachyderma on palms and soles. Her blood arsenic level was 7. 3 μg/L, and her urine arsenic level was 0.117 mg/L. Chronic arsenic poisoning was diagnosed. After completing three courses of therapy with sodium dimercaptopropane sulfonate, her symptoms markedly improved. Patient 2, a 40-year-old man, received 20 - 80 Xiaoerqizhen pills one to two times daily for 7 years for constipation. During the treatment, he gradually presented with fatigue, anorexia, nausea, abdominal distension, pigmentation over his entire body, severe keratodermia, and numbness of extremities, hepatoemegaly, splenomegaly, and anemia. His urine arsenic level was 4.28 mg/L. He was diagnosed with chronic arsenic poisoning. After completing five courses of therapy with sodium dimercaptopropane sulfonate, his symptoms were markedly improved and he was discharged.
出处
《药物不良反应杂志》
2009年第1期35-36,共2页
Adverse Drug Reactions Journal
关键词
小儿七珍丸
慢性砷中毒
不良反应
Xiaoerqizhen pills
chronic arsenic poisoning
adverse reactions
